Sp1149 I: Constraints on the Balmer L-sigma Relation for HII Regions in a Spiral Galaxy at Redshift z=1.49 Strongly Lensed by the MACS J1149 Cluster [PDF]
, 2023 Hayley Williams +5 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Sigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics [PDF]
, 2023 Reed L. Berkowitz +5 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Prevalence of toxoplasmosis in pregnant women treated at San Diego clinic in Barranquilla, Colombia
Ciencia y SaludIntroduction: Toxoplasmosis is an infectious disease produced by the parasite Toxoplasma gondii. The occurrence of the infection during pregnancy generates severe complications for the fetus, leaving important neurological and visual sequelae.
Aracely García-Cuan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Six Sigma Practices Integrated with IR 4.0 for Sustainability in Malaysian Healthcare Industry
, 2022 Diekola Akanmu, Norshahrizan Nordin
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Pengendalian Kualitas Metode Six Sigma Untuk Mengurangi Tingkat Kerusakan Produk Kalender Di PT. KLM
, 2022 Agustian Waruwu +3 more
openalex +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source