Results 161 to 170 of about 1,815,787 (311)

Intermittent fasting enhances cisplatin-metformin efficacy in therapy-resistant ovarian cancer PDXs. [PDF]

iScience
Capellini E, Perotti L, Guffanti F, De Simone G, Morabito A, Ronchi AM, Sala L, Scanziani E, Corna D, Cerullo D, Matteo C, Fruscio R, Brunelli L, Damia G, Ricci F.   +14 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Sigma-1 receptors, alcohol consumption, and arterial tone: a new intersection in cardiovascular physiology. [PDF]

Am J Physiol Heart Circ Physiol
Redmond EM, Cahill PA.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Advancing depression treatment: the role of sigma receptor ligands. [PDF]

Front Neurosci
Zhang P, Ning Z, Chen H, Chen J, Lu Z, Xu F.   +5 more
europepmc   +1 more source

Application of Industry Recognised Development Tools and Methodologies, such as Six Sigma to Facilitate the Efficient Delivery of Innovative and Robust Engineering Solutions at Synchrotron Facilities

, 2018
Sarah Macdonell
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Enhancement in production efficiency using DMAIC methodology of six sigma. [PDF]

Sci Rep
Deepak D, Farwaha HS, Alqahtani FM, Dwivedi S, Singh RP, Singh P, Ranjan N, Kumar A.   +7 more
europepmc   +1 more source

Evaluation of the composite action of cold-formed steel built-up battened columns composed of two sigma-shaped sections

, 2022
Rohola Rahnavard, Mahtabsadat Razavi, Nader Fanaie, Hélder D. Craveiro   +3 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source