Results 41 to 50 of about 1,815,787 (311)

Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis

open access: yesJournal of Lipid Research, 1997
Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways.
L Lligona-Trulla   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Information technology governance in University of Muhammadiyah Palembang using framework COBIT 5 domain; Evaluate, Direct and Monitor (EDM)

open access: yesIlkom Jurnal Ilmiah, 2022
This study aims to find out about Information Technology management at Muhammadiyah University of Palembang and to get right advice in managing Information Technology from the University level to the Study Program.
Zulhipni Reno Saputra Elsi   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Analysis of unqualified pre-analytical samples in blood station laboratories in North China

open access: yesZhongguo shuxue zazhi
[Objective] To determine the frequency and main reasons of unqualified samples by analyzing the quality of pre-analytical samples in blood stations in North China, thereby providing a reference and basis for gap analysis in the implementation of pre ...
LIU Zhengmin   +7 more
doaj   +1 more source

Sigma metrics in clinical chemistry laboratory – A guide to quality control [PDF]

open access: yesAl Ameen Journal of Medical Sciences, 2015
Background: Six sigma is a process of quality measurement and improvement program used in industries. Sigma methodology can be applied wherever an outcome of a process is to be measured. A poor outcome is counted as an error or defect. This is quantified
Usha S. Adiga, A. Preethika, K. Swathi
doaj  

Encouraging student-driven clinical research in Germany: the CHIR-Net SIGMA network

open access: yesInnovative Surgical Sciences, 2017
Evidence should define and guide modern clinical care, yet many relevant questions in surgical practice remain unconfirmed by substantial data. Evidence-based medicine requires both the implementation of its principles in day-to-day work and the ...
Frey Pia-Elena   +7 more
doaj   +1 more source

The impact of staff turnover and staff density on treatment quality in a psychiatric clinic

open access: yesFrontiers in Psychology, 2016
Intuition suggests that improving stability of the health workforce brings benefits to staff, the organization and, most importantly, the patients. Unfortunately, there is limited research available to support this, and how health workforce stability can
Wolfram Alexis Brandt   +2 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Evaluation of analytical performance of Variant II Turbo HbA1c analyzer according to SIGMA metrics [PDF]

open access: yesJournal of Medical Biochemistry, 2019
Background: Hemoglobin A 1c, (HbA1c) which is the major constituent of glycated hemoglobin, has been used in the follow-up of retrospective glycemia for years and in the diagnosis of diabetes mellitus nowadays.
Bozkaya Giray   +3 more
doaj  

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