Results 71 to 80 of about 1,815,787 (311)

Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain

Pharmaceuticals
Background/Objectives: Neuropathic pain remains a significant clinical challenge, with current treatments often providing inadequate relief and adverse effects.
Ryosuke Shinouchi, Bengisu Turgutalp, Rohini S. Ople, Shainnel O. Eans, Ashai K. Williams, Haylee R. Hammond, Andras Varadi, Rebecca Notis Dardashti, Susruta Majumdar, Jay P. McLaughlin   +9 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Towards rare-earth-free white light-emitting diode devices based on the combination of dicyanomethylene and pyranine as organic dyes supported on zinc single-layered hydroxide

Beilstein Journal of Nanotechnology, 2019
A new luminescent composite film resulting from the dispersion of luminescent organic dyes in a single-layered hydroxide (SLH)-type inorganic matrix has been developed.
Jeff L. Nyalosaso, Rachod Boonsin, Pierre Vialat, Damien Boyer, Geneviève Chadeyron, Rachid Mahiou, Fabrice Leroux   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Measurement of the differential cross sections of the Sigma-p elastic scattering in momentum range of 470 to 850 MeV/c [PDF]

, 2021
J-PARC E Collaboration, Miwa, K., K. Miwa, J. K. Ahn, Y. Akazawa, T. Aramaki, S. Ashikaga, S. Callier, N. Chiga, Sung-Wook Choi, H. Ekawa, P. Evtoukhovitch, N. Fujioka, Masaya Fujita, T. Gogami, T. Harada, S. Hasegawa, S. Hayakawa, R. Honda, Satoshi Hoshino, K. Hosomi, M. Ichikawa, Y. Ichikawa, M. Ieiri, M. Ikeda, K. Imai, Yuji Ishikawa, S. Ishimoto, Wooseung Jung, S. Kajikawa, H. Kanauchi, Hiroyuki Kanda, T. Kitaoka, B. M. Kang, H. Kawai, S. H. Kim, Kazuya Kobayashi, T. Koike, Kenji Matsuda, Y. Matsumoto, S. Nagao, Ryoichi Nagatomi, Yasuki Nakada, Mayumi Nakagawa, I. Nakamura, T. Nanamura, M. Naruki, Seiji Ozawa, L. Raux, T. G. Rogers, A. Sakaguchi, T. Sakao, H. Sako, Sayaka Sato, T. Shiozaki, K. Shirotori, Kanichi Suzuki, Satoshi Suzuki, M. Tabata, C. De La Taille, H. Takahashi, T. Takahashi, T. Takahashi, Hideo Tamura, M. Tanaka, K. Tanida, Z. Tsamalaidze, M. Ukai, H. Umetsu, S. Wada, T. O. Yamamoto, Junya Yoshida   +71 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Silver Doping Mechanism in Bioceramics—From Ag⁺:Doped HAp to Ag°/BCP Nanocomposite

Crystals, 2019
The results presented in this paper, based on the powder X-ray diffraction technique followed by Rietveld analyses, are devoted to the mechanism of silver incorporation in biphasic calcium phosphates. Results were confirmed by SEM observation.
Aurélie Jacobs, Morgane Gaulier, Alexis Duval, Guillaume Renaudin   +3 more
doaj   +1 more source