Results 31 to 40 of about 7,582 (263)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
DESIGN AND SIMULATION OF HIGH PRECISION SECOND-ORDER SIGMA-DELTA MODULATOR FOR BLUETOOTH APPLICATIONS [PDF]
Journal of Engineering Science and Technology, 2018 A second-order sigma-delta modulator is presented in this paper which, according to the considered standards, is suitable for bluetooth applications. The oversampling ratio and signal bandwidth of the proposed modulator is 128 and 1 MHz, respectively ...
MOHAMMAD REZA FARSI, KHALIL MONFAREDI
doaj
Realization of DVCCTA Based Versatile Modulator
Active and Passive Electronic Components, 2014 A Differential Voltage Current Conveyor Transconductance Amplifier (DVCCTA) based versatile modulator is proposed which can work as an amplitude modulator, frequency modulator, delta modulator, and sigma delta modulator.
Neeta Pandey +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Adaptive Delta-Sigma Modulation for Enhanced Input Dynamic Range
EURASIP Journal on Advances in Signal Processing, 2008 An adaptive delta-sigma modulator of 1st order with one-bit quantization is presented. Adaptation is instantaneous and based on an exponential law. The feedback signal is a multibit discrete-level signal generated by a digital-to ...
Clemens M. Zierhofer
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Low Power, Low Area Digital Modulators using Gate Diffusion Input Technique
Journal of King Saud University: Engineering Sciences, 2019 Audio playback devices like IPODs and MP3 players use Sigma Delta Digital to Analog Converters (DACs) where the size and power consumption is of prime importance. Digital modulator is the most important part of Sigma Delta DACs. This paper presents a new
Anuja Askhedkar, Girdharilal Agrawal
doaj +1 more source
Applied Sciences, 2020 This paper is an extension of the existing works on the frequency-domain-based bit flipping control strategy for stabilizing the single-bit high-order interpolative sigma delta modulator. In particular, this paper proposes the implementation and performs
Huishan Zhai, Bingo Wing-Kuen Ling
doaj +1 more source
A Single-Bit Incremental Second-Order Delta-Sigma Modulator with Coarse-Fine Input Buffer
Applied Sciences, 2022 This paper presents an incremental second-order delta-sigma modulator with a coarse-fine input buffer in 180-nm CMOS. The modulator’s architecture was implemented as a second-order cascade of integrators with a feedback structure.
Mookyoung Yoo +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source