Results 111 to 120 of about 2,302,822 (346)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Modelo de referência para estruturar o Seis Sigma nas organizações Reference model to structure the Six Sigma in organizations

Gestão & Produção, 2008
Este artigo apresenta o modelo de referência para estruturar o Seis Sigma, o qual é resultante da incorporação de teorias que contribuem para aumentar o potencial estratégico do Seis Sigma no sentido de incrementar o desempenho organizacional.
Adriana Barbosa Santos, Manoel Fernando Martins   +1 more
doaj   +1 more source

Search for the QCD Critical Point: Higher Moments of Net-proton Multiplicity Distributions

, 2011
Higher moments of event-by-event net-proton multiplicity distributions have been applied to search for the QCD critical point. Model results are used to provide a baseline for this search.
A. Kisiel, B. I. Abelev, Bedangadas Mohanty, F. Karsch, Hans Georg Ritter, J. Adams, M. A. Stephanov, M. A. Stephanov, M. Cheng, M. Gyulassy, M. M. Aggarwal, Nu Xu, S. Ejiri, X. F. Luo, Xiaofeng Luo, Y. Aoki, Y. Hatta, Z.-W. Lin   +17 more
core   +1 more source

Quantum corrections of Abelian Duality Transformations [PDF]

, 1996
A modification of the Abelian Duality transformations is proposed guaranteeing that a (not necessarily conformally invariant) $\sigma$-model be quantum equivalent (at least up to two loops in perturbation theory) to its dual. This requires a somewhat non
Balog, J., Forgács, P., Horváth, Z., Palla, L.   +3 more
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Six sigma implementation model based on critical success factors (CSFs) for indonesian small and medium industries

MATEC Web of Conferences, 2018
This study aims to build a model of critical success factors in the application of Six Sigma for Indonesian small and medium industries and their relation to the industry performance.
Yuri M. Zagloel a Teuku, Ardi b Romadhani, Poncotoyo Wahyu   +2 more
doaj   +1 more source

Local β-deformations and Yang-Baxter sigma model

Journal of High Energy Physics, 2018
Homogeneous Yang-Baxter (YB) deformation of AdS5 × S5 superstring is revisited. We calculate the YB sigma model action up to quadratic order in fermions and show that homogeneous YB deformations are equivalent to β-deformations of the AdS5 ×S5 background
Jun-ichi Sakamoto, Yuho Sakatani
doaj   +1 more source