Results 141 to 150 of about 2,302,822 (346)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Dualisation of the principal sigma model
, 2008 The first-order formulation of the principal sigma model with a Lie group target space is performed. By using the dualisation of the algebra and the field content of the theory the field equations which are solely written in terms of the field strengths ...
Yilmaz, Nejat Tevfik
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Emergence of charm-strange dibaryons with negative parity via baryon–baryon interactions
European Physical Journal C: Particles and FieldsWithin the framework of the one-boson-exchange model, we systematically perform a coupled channel analysis of the $$P-$$ P - wave interactions between a charm baryon and light baryon, the involved channels include $$\Xi _cN$$ Ξ c N , $$\Lambda _c\Sigma $$
Yu-Yue Cui +3 more
doaj +1 more source
Study on improving silicone losses in the process of mixing components of soldering machines
MATEC Web of Conferences, 2018 The paper presents a summary of the steps of the 6 Sigma methodology applied in the gluing section within an automotive company form Sibiu, Romania. We describe the synthesis of each step of the DMAIC model, a well-known model in the application of the 6
Victor Zerbes Mihai +1 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The second-order renormalization group flow for nonlinear sigma models in two dimensions [PDF]
, 2009 Todd A Oliynyk
openalex +1 more source
Is the $\sigma$ meson dynamically generated?
, 2006 We study the problem whether the $\sigma$ meson is generated `dynamically'. A pedagogical analysis on the toy O(N) linear sigma model is performed and we find that the large $N_c$ limit and the $m_\sigma\to \infty$ limit does not commute. The sigma meson
Guo, Zhi-hui, Xiao, L. Y., Zheng, H. Q.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source