Results 151 to 160 of about 9,106,328 (402)

An Efficient Thiol‐ene Mediated Protocol for Thiolated Peptide Synthesis and On‐Resin Diversification

Chemistry – A European Journal, EarlyView.
Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa, Conor Williams, Konstantin Raabe, Joshua T. McLean, Markus Muttenthaler, Eoin M. Scanlan   +5 more
wiley   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Absence of Alpha-Synuclein Aggregation in Patients With Parkinson’s Disease Complicated by Sigmoid Volvulus [PDF]

, 2023
Dallah Yoo, Jae Young Joo, Sung‐Hye Park, Sun Jin Park, Tae‐Beom Ahn   +4 more
openalex   +1 more source

Woman with Sickle Cell Disease with Current Sigmoid Sinus Thrombosis and History of Inadequate Warfarin Use during a Past Thrombotic Event [PDF]

, 2009
Asuman Çelikbilek, Mehmet Çelikbilek, Alper Bozkurt, Başak Karakurum Göksel, Meli̇ha Tan, Hakan Özdoğu   +5 more
openalex   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Magnetic Helicity Signs and Flaring Propensity: Comparing Force-free Parameter with the Helicity signs of Hα Filaments and X-ray Sigmoids [PDF]

arXiv
Sigmoids produce strong eruptive events. Earlier studies have shown that the ICME axial magnetic field Bz can be predicted with some credibility by observing the corresponding filament or the polarity inversion line in the region of eruption and deriving the magnetic field direction from that.
arxiv  

Smoking Increases the Incidence of Complicated Diverticular Disease of the Sigmoid Colon [PDF]

, 2010
Pauli M. Turunen, Heidi Wikström, Monika Carpelan‐Holmström, P. Kairaluoma, Olli Kruuna, Tom Scheinin   +5 more
openalex   +1 more source

Crohn’s Disease Complicated by Ileosigmoid Fistula – Synchronous Resection or Primary Sigmoid Repair, One or Two-stage Procedure? A systematic review of the literature and prospective case series [PDF]

, 2020
Georgi Popivanov, D. Stoyanova, Marina Konaktchieva, Roberto Cirocchi, Dimitar Penchev, Kirien T. Kjossev, Pencho Tonchev, Ventsislav Mutafchiyski   +7 more
openalex   +1 more source

Deciphering Important Metabolic Pathways through Reaction Pair Prediction with a Siamese Transformer Network

Chemistry–Methods, EarlyView.
A deep learning‐based method Siamese transformer reaction pair (STRP) prediction is presented for identifying important pathways in untargeted LC‐MS/MS metabolomics. STRP accurately predicts metabolic reaction pairs from known metabolites and tandem mass spectra of unannotated metabolic features, which enhance the utility of untargeted metabolomics ...
Han Bao, Xinxin Wang, Jinhui Zhao, Bin Wang, Xinjie Zhao, Chunxia Zhao, Xin Lu, Guowang Xu   +7 more
wiley   +1 more source

Machine Learning–Driven Screening of High‐Activity Antitumor Nanozymes Using an Ensemble Enzymatic Oracle System

Cancer Nexus, EarlyView.
ABSTRACT Nanozymes, by mimicking the catalytic sites of natural enzymes, have emerged as effective substitutes for traditional natural enzymes. However, the relationship between the physicochemical properties and activity of nanozymes is complex and nonlinear.
Guanmeng Zhang, Mutian Yang, Jie Zang, Xiaoli Li, Qinqiu Zhong, Yuxiang Hu, Yumeng Xie, Ludan Zhang, Yuping Qian, Jinna Ren, Yang Peng, Haitao Chen, Jiandong Gao, Ji Wu, Yuguang Wang   +14 more
wiley   +1 more source