Results 241 to 250 of about 44,356 (288)

The emperor has no clothes-the need for standardized anatomical segment definitions in the management of colon cancer. [PDF]

Int J Colorectal Dis
Kutlu B, Benlice C, Seker ME, Kocaay AF, Kuzu MA.   +4 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Combined water exchange and cap-assisted colonoscopy reduces cecal intubation time and patient discomfort in patients with unsedated colonoscopy: a randomized controlled trial. [PDF]

BMC Gastroenterol
Wang D, Wang A, Ding X, Zhou R.
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Techniques in coloproctology - controversies in coloproctology resection: rectopexy is an underutilised procedure in the management of both symptomatic high-grade internal and external rectal prolapse. [PDF]

Tech Coloproctol
Bunni J, Courtney ED.
europepmc   +1 more source

Humoral epitope dominance and immune imprinting by SARS‐CoV‐1 and SARS‐CoV‐2 vaccines

Immunology &Cell Biology, EarlyView.
We investigated Modified Vaccinia Ankara (MVA) vaccine candidates expressing the SARS‐CoV‐1 or SARS‐CoV‐2 Spike, as a primary or booster immunization, for their ability to induce antibodies targeting different epitopes on the SARS‐CoV‐2 RBD and broad cross‐reactive or cross‐neutralizing responses in C57BL/6 and antibody humanized (Ig‐humanized) mice ...
Deborah L Burnett, Ania Moxon, Anupriya Aggarwal, Katherine JL Jackson, Catherine Cotter, Anouschka Akerman, Amanda Russell, Rachel Kalman, David Langley, Jake Y Henry, Daniel Christ, Rowena A Bull, Robert Brink, Anthony D Kelleher, Hans‐Martin Jäck, Stuart Turville, Bernard Moss, Christopher C Goodnow   +17 more
wiley   +1 more source

Unmasking the false cecal polyp: a case of inverted appendix-a case report and review of the literature. [PDF]

J Surg Case Rep
Weiss T, Karni D, Zilbermints V, Kessel B, Gal O.   +4 more
europepmc   +1 more source

Editorial Perspective: How spreading mental health information can be (un‐) helpful – a dynamic systems approach

Journal of Child Psychology and Psychiatry, EarlyView.
Increasing awareness of mental health problems, including that of young people, is generally seen as positive, and many interventions to increase awareness are underway internationally. Yet, a principled evaluation of the benefits and harms of increasing awareness is still lacking.
Daniele Marcotulli, Lucy Foulkes, Argyris Stringaris   +2 more
wiley   +1 more source

The feasibility, safety and short-term clinical efficacy of laparoscopic resection rectopexy with natural orifice specimen extraction surgery for the treatment of complete rectal prolapse. [PDF]

BMC Surg
Chen S, Zhang J, Liang Y, Tang R, Yuan S, Xie S, Wang Q, Zhang C.   +7 more
europepmc   +1 more source

Brain tissue classification in hyperspectral images using multistage diffusion features and transformer

Journal of Microscopy, EarlyView.
Abstract Brain surgery is a widely practised and effective treatment for brain tumours, but accurately identifying and classifying tumour boundaries is crucial to maximise resection and avoid neurological complications. This precision in classification is essential for guiding surgical decisions and subsequent treatment planning.
Neetu Sigger, Tuan T. Nguyen, Gianluca Tozzi   +2 more
wiley   +1 more source