Results 131 to 140 of about 217,698 (308)

Some special families of holomorphic and Sălăgean type bi-univalent functions associated with Horadam polynomials involving a modified sigmoid activation function

, 2021
Sondekola Rudra Swamy, Serap Bulut, Yerragunta Sailaja   +2 more
openalex   +2 more sources

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Update Disturbance‐Resilient Analog ReRAM Crossbar Arrays for In‐Memory Deep Learning Accelerators

Advanced Science, EarlyView.
Conductive metal oxide/HfOx analog ReRAM on 350 nm technology is presented for in‐memory deep learning accelerators. The device exhibits analog and nonvolatile conductance switching and high resilience to update disturbances, which is supported by COMSOL Multiphysics simulations.
Wooseok Choi, Tommaso Stecconi, Donato Francesco Falcone, Matteo Galetta, Victoria Clerico, Elisa Zaccaria, Mamidala Saketh Ram, Antonio La Porta, Folkert Horst, Daniel Jubin, Matias Senger, Marilyne Sousa, Steffen Reidt, Ralph Heller, Bernabe Linares‐Barranco, Valeria Bragaglia, Bert Jan Offrein   +16 more
wiley   +1 more source

Multifactor prediction model for stock market analysis based on deep learning techniques

Scientific Reports
Stock market stability relies on the shares, investors, and stakeholders’ participation and global commodity exchanges. In general, multiple factors influence the stock market stability to ensure profitable returns and commodity transactions.
Kangyi Wang
doaj   +1 more source

Characterisation of basin water allocation benefit function using a sigmoid-type S-curve logistic equation

Aqua
As water allocation (WA) is reduced due to water scarcity in a river basin, the benefit function for the domestic water users and the economic sectors declines accordingly.
Ahmad Fakhri Ishak, Wei Koon Lee, Foo Hoat Lim   +2 more
doaj   +1 more source

The Foundation and Validation of Sigmoid-Typed Functions for Fouling Formation Modelling of Crude Oil Flows

, 2023
Gunawan Nugroho, Novandion R. Kurniawan, Totok R. Biyanto, Purwadi Agus Darwito, Titik Budiati   +4 more
openalex   +2 more sources

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

Smooth Sigmoid Surrogate (SSS): An Alternative to Greedy Search in Decision Trees

Mathematics
Greedy search (GS) or exhaustive search plays a crucial role in decision trees and their various extensions. We introduce an alternative splitting method called smooth sigmoid surrogate (SSS) in which the indicator threshold function used in GS is ...
Xiaogang Su, George Ekow Quaye, Yishu Wei, Joseph Kang, Lei Liu, Qiong Yang, Juanjuan Fan, Richard A. Levine   +7 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source