Results 171 to 180 of about 10,487,885 (363)

Soft Bioelectronic Interfaces for Continuous Peripheral Neural Signal Recording and Robust Cross‐Subject Decoding

open access: yesAdvanced Science, EarlyView.
A soft poly (3,4‐ethylenedioxythiophene):poly (styrenesulfonate)‐based electrode enables continuous, high‐quality recording of peripheral nerve activity. A neural network model integrating handcrafted and convolutional neural network‐based features decodes whisker movements with strong generalization, offering insights into peripheral nerve function ...
Liangpeng Chen   +22 more
wiley   +1 more source

Pressure‐Induced Ultralow Critical Micelle Concentration of Surfactant for Encapsulating Dye

open access: yesAdvanced Science, EarlyView.
Ultralow critical micelle concentration (CMC) is successfully achieved by pressure. Compared to 917.2 ± 8.7 µm for cetyl trimethyl ammonium bromide at 0.10 MPa, the ultralow CMC at 0.80 GPa is a ≈111‐fold reduction for 8.3 ± 0.1 µm. The detection of ultralow CMC under pressure is owed to the pressure‐induced fluorescence quenching of the coumarin 35 ...
Qi Li   +7 more
wiley   +1 more source

Justifying the prediction of major soil nutrients levels (N, P, and K) in cabbage cultivation

open access: yesMethodsX
In a recent paper by Sajindra et al. [1], the soil nutrient levels, specifically nitrogen, phosphorus, and potassium, in organic cabbage cultivation were predicted using a deep learning model.
Thilina Abekoon   +5 more
doaj  

An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

open access: yesAdvanced Science, EarlyView.
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang   +11 more
wiley   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

open access: yesAdvanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee   +3 more
wiley   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

open access: yesAdvanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao   +13 more
wiley   +1 more source

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