Results 11 to 20 of about 211 (131)

The impact of circular stapler size on the risk of anastomotic stricture following total mesorectal excision in rectal cancer patients: A retrospective cross‐sectional study

open access: yesHealth Science Reports, Volume 6, Issue 10, October 2023., 2023
Abstract Introduction Colorectal cancer (CRC) surgery complications are a major issue affecting morbidity and mortality rates. Anastomotic stricture, which occurs in almost 30% of patients after surgery for rectal cancer, is one of the most serious but underreported side effects.
Behnam Behboudi   +10 more
wiley   +1 more source

Effects of glepaglutide, a long‐acting glucagon‐like peptide‐2 analog, on intestinal morphology and perfusion in patients with short bowel syndrome: Findings from a randomized phase 2 trial

open access: yesJournal of Parenteral and Enteral Nutrition, Volume 47, Issue 1, Page 140-150, January 2023., 2023
Abstract Background The proadaptive effects of glucagon‐like peptide‐2 (GLP‐2) include stimulation of intestinal mucosal growth as well as intestinal blood flow and angiogenesis. We have recently reported that daily subcutaneous injections of glepaglutide, a long‐acting GLP‐2 analog, improved intestinal absorptive function in patients with short bowel ...
Rahim M. Naimi   +9 more
wiley   +1 more source

Exposure to oestrogen and risk of anastomotic leakage after colorectal cancer surgery – A clue to the different leak rates in men and women

open access: yesColorectal Disease, Volume 25, Issue 1, Page 9-15, January 2023., 2023
Abstract Background Colorectal anastomotic leakage is consistently more common in men, regardless of tumour location. This fact is largely unexplained but might be a consequence of biological differences including hormonal exposure and not only related to anatomy.
Martin Rutegård   +5 more
wiley   +1 more source

Long term oncological outcomes for laparoscopic versus open surgery for rectal cancer – A population‐based nationwide noninferiority study

open access: yesColorectal Disease, Volume 24, Issue 11, Page 1308-1317, November 2022., 2022
Abstract Aim The aim of this work was to compare the 5‐year overall survival in a national cohort of patients undergoing curative abdominal resection for rectal cancer by laparoscopic (LAP) or open (OPEN) surgery. Method All patients diagnosed with clinical Stage I–III rectal cancer and who underwent LAP or OPEN abdominal curative surgery in Sweden ...
Kaveh Dehlaghi Jadid   +4 more
wiley   +1 more source

Postoperative nonsteroidal anti‐inflammatory drugs in relation to recurrence, survival and anastomotic leakage after surgery for colorectal cancer

open access: yesColorectal Disease, Volume 24, Issue 8, Page 933-942, August 2022., 2022
Abstract Aim The aim of this work was to investigate whether nonsteroidal anti‐inflammatory drugs (NSAIDs) could be beneficial or harmful when used perioperatively for colorectal cancer patients, as inflammation may affect occult disease and anastomotic healing.
Oskar Grahn   +5 more
wiley   +1 more source

Rectal washout during abdominoperineal resection for rectal cancer has no impact on the oncological outcome

open access: yesColorectal Disease, Volume 24, Issue 3, Page 284-291, March 2022., 2022
Abstract Aim Intraoperative rectal washout is performed to eliminate exfoliated intraluminal cancer cells and thereby decrease the risk of local recurrence. Rectal washout in abdominoperineal resection has not been studied. The aim of this study was to assess the oncological outcome after rectal washout in abdominoperineal resection for rectal cancer ...
Rebecca Svensson Neufert   +2 more
wiley   +1 more source

Vitamin D treatment induces in vitro and ex vivo transcriptomic changes indicating anti‐tumor effects

open access: yesThe FASEB Journal, Volume 36, Issue 1, January 2022., 2022
Abstract Vitamin D deficiency is associated with risk of several common cancers, including colorectal cancer (CRC). Here we have utilized patient derived epithelial organoids (ex vivo) and CRC cell lines (in vitro) to show that calcitriol (1,25OHD) increased the expression of the CRC tumor suppressor gene, CDH1, at both the transcript and protein level.
Peter G. Vaughan‐Shaw   +13 more
wiley   +1 more source

Cryopyrin‐associated periodic syndrome with inflammatory bowel disease: A case study

open access: yesJGH Open, Volume 5, Issue 5, Page 629-631, May 2021., 2021
Cryopyrin‐Associated Periodic Syndrome (CAPS) is a rare, autoinflammatory condition, caused by NLRP3 gene mutations and managed by interleukin 1 blockade. Here, a gastrointestinal manifestation with CAPS was successfully treated with anti‐TNF infliximab, maintained with anakinra. Abstract Cryopyrin‐associated Periodic Syndrome (CAPS) is a rare, genetic
Karen N Raymond, Jonathan E D Martin
wiley   +1 more source

The Association of Coloproctology of Great Britain and Ireland consensus guidelines in emergency colorectal surgery

open access: yesColorectal Disease, Volume 23, Issue 2, Page 476-547, February 2021., 2021
Abstract Aim There is a requirement for an expansive and up to date review of the management of emergency colorectal conditions seen in adults. The primary objective is to provide detailed evidence‐based guidelines for the target audience of general and colorectal surgeons who are responsible for an adult population and who practise in Great Britain ...
Andrew S. Miller   +12 more
wiley   +1 more source

Barriers to flexible sigmoidoscopy colorectal cancer screening in low uptake socio‐demographic groups: A systematic review

open access: yesPsycho-Oncology, Volume 29, Issue 8, Page 1237-1247, August 2020., 2020
Abstract Objective To synthesise qualitative evidence related to barriers and facilitators of flexible sigmoidoscopy screening (FSS) intention and uptake, particularly within low socio‐demographic uptake groups. FSS uptake is lower amongst women, lower socio‐economic status (SES), and Asian ethnic groups within the United Kingdom (UK) and United States
Elizabeth Travis   +3 more
wiley   +1 more source

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