Results 251 to 260 of about 1,610,325 (309)

From Multi‐Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR‐T Cell Therapy

open access: yesAdvanced Science, EarlyView.
This review explores how multi‐omics, visualization technologies, and AI drive CAR‐T therapy from the micro to the macro level, from preclinical studies to clinical applications. The convergence of these approaches provides deeper insight into CAR‐T cell mechanisms, aids in structural optimization, and significantly enhances treatment efficacy and ...
Yuting Gong   +4 more
wiley   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang   +9 more
wiley   +1 more source

Vermicular Eutectic Multi‐Principal Element Alloy with Exceptional Strength and Ductility

open access: yesAdvanced Science, EarlyView.
Eutectic multi‐principal element alloys (EMPEAs) typically exhibit rod‐like or lamellar microstructures, constraining further mechanical improvements. This study introduces a novel (AlCrFe2)65Ni35 EMPEA with a unique vermicular microstructure, achieving unprecedented strength‐ductility synergy.
Liufei Huang   +11 more
wiley   +1 more source

Piezoresistive Effect: A New Concept for Hearing Aids

open access: yesAdvanced Science, EarlyView.
An MXene/PVA sound sensor utilizing piezoresistive effects has been proposed with a detection limit of 60 dB and a frequency response of 20–4000 Hz, which is comparable to the performance of commercial hearing aids. By combining the sensor with machine learning, the accuracy rate of voiceprint recognition of wildlife conservation can reach up to 99 ...
Mengyao Gao   +8 more
wiley   +1 more source

Mercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus

open access: yesAdvanced Science, EarlyView.
This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...
Qing Yu   +7 more
wiley   +1 more source

Superelastic and Ultra‐Soft MXene/CNF Aerogel@PDMS‐Based Dual‐Modal Pressure Sensor for Complex Stimuli Monitoring

open access: yesAdvanced Science, EarlyView.
A triboelectric‐piezoresistive dual‐modal pressure sensor based on superelastic and ultrasoft MXene/cellulose nanofiber (CNF) aerogel@PDMS is fabricated. The sensor exhibits high sensitivity and stable sensing performance via a dual mechanism. Through the effective combination of these two mechanisms, comprehensive monitoring of complex stimuli can be ...
Ao Wang   +9 more
wiley   +1 more source

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