Results 51 to 60 of about 573,942 (348)

Sign duration and signing rate in British Sign Language, Dutch Sign Language and Swedish Sign Language

open access: yesGlossa Psycholinguistics
In this article, we look at sign duration and signing rate in corpora of three sign languages – British Sign Language (BSL), Dutch Sign Language (NGT), and Swedish Sign Language (STS). We investigate whether token frequency and sociolinguistic variables (e.g., age, gender, region) influence the production rate of signing.
Carl Börstell   +2 more
openaire   +3 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Time Is Ripe to Make Interactional Moves: Bringing Evidence From Four Languages Across Modalities

open access: yesFrontiers in Communication, 2022
Sign language linguistics has largely focused on lexical, phonological, and morpho-syntactic structures of sign languages, leaving the facets of interaction overlooked. One reason underlying the study of smaller units in the initial stages of development
Alysson Lepeut, Emily Shaw
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Absolute spatial deixis and proto-toponyms in Kata Kolok [PDF]

open access: yes, 2014
This paper presents an overview of spatial deictic structures in Kata Kolok, a sign language which is indigenous to a Balinese village community. Sociolinguistic surveys and lexicographic comparisons have indicated that Kata Kolok is unrelated to the ...
De Vos, Connie
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Word Formation below and above Little x:
Evidence from Sign Language of the Netherlands

open access: yesNordlyd: Tromsø University Working Papers on Language & Linguistics, 2004
Although in many respects sign languages have a similar structure to that of spoken languages, the different modalities in which both types of languages are expressed cause differences in structure as well.
Inge Zwitserlood
doaj   +1 more source

Is Lhasa Tibetan Sign Language emerging, endangered, or both? [PDF]

open access: yes, 2017
This article offers the first overview of the recent emergence of Tibetan Sign Language (TibSL) in Lhasa, capital of the Tibet Autonomous Region (TAR), China.
Hofer, Theresia
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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