Results 231 to 240 of about 4,892,908 (297)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Control Design for Signal Transduction Networks

Bioinformatics and Biology Insights, 2009
Chun-Liang Lin, Yuan-Wei Liu, Chia-Hua Chuang   +2 more
doaj  

Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery. [PDF]

J Immunother Cancer
Luly KM, Zhou XMM, Surwase SS, Rocher EE, Kollings J, Lu C, Will E, Zhu Q, Anders RA, Green JJ, Tzeng SY, Sunshine JC.   +11 more
europepmc   +1 more source

Correlating Stimulated Emission Depletion Microscopy With Fluorescence Lifetime Imaging Microscopy to Study the TIE2 Protein on Kidney Glomerular Podocytes. [PDF]

J Histochem Cytochem
Dénes IA, Okkelman IA, Keersmaecker H, Cornillie P, Dmitriev RI, De Spiegelaere W.   +5 more
europepmc   +1 more source

Integrated optimization of spatiotemporal resources at the intersection for delay minimization using genetic algorithm. [PDF]

PLoS One
Yang Z, Wu L, Li G, Xu Y, Liu W.
europepmc   +1 more source

High-sensitivity spin-exchange relaxation-free (SERF) magnetometry combined with magnetic-responsive iron oxide nanoparticles for real-time monitoring of malignant tumor therapy. [PDF]

Theranostics
Wang W, Zhang G, Wang B, Zhou D, Ding N, Huang Z, Zheng S, Cheng Q, Yu M, Xiang M, Chen Y, Duan J, Yu D.   +12 more
europepmc   +1 more source

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CD98 signals controlling tumorigenesis

The International Journal of Biochemistry & Cell Biology, 2016
CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways.
Hugh, Ip, Tariq, Sethi
openaire   +2 more sources

Control of semaphorin signaling

Current Opinion in Neurobiology, 2002
Receptor complexes for the chemorepellent factors of the semaphorin family activate intracellular pathways that trigger actin rearrangements underlying growth cone collapse and repellent behavior. Some evidence has been provided for a complex and dynamic pattern of interaction between members of the small Rho guanosine triphosphatases and plexin ...
Castellani, Valérie, Rougon, Geneviève
openaire   +4 more sources