Results 121 to 130 of about 9,828,805 (358)

IBPF-RRT*: An improved path planning algorithm with Ultra-low number of iterations and stabilized optimal path quality

open access: yesJournal of King Saud University: Computer and Information Sciences
Due to its asymptotic optimality, the Rapidly-exploring Random Tree star (RRT*) algorithm is widely used for robotic operations in complex environments. However, the RRT* algorithm suffers from poor path quality, slow convergence, and unstable generation
Haidong Wang   +3 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Biological Knowledge Graph-Enhanced Cancer State Prediction Network with Adjustable Connections

open access: yesBig Data Mining and Analytics
With recent advances in oncology research, effectively utilizing patient genomic data to predict cancer status has become a significant challenge. Although previous deep learning methods based on biological knowledge have made progress, they still face ...
Yuhan Liu   +4 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

A deep-learning based high-gain method for underwater acoustic signal detection in intensity fluctuation environments

open access: green, 2023
H. Chu   +7 more
openalex   +2 more sources

Multichannel signal detection in interference and noise when signal mismatch happens [PDF]

open access: yesSignal Processing, 2019
Weijian Liu   +4 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

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