Results 191 to 200 of about 517,295 (253)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Induction of subtle blood-brain barrier dysfunction using preclinical diagnostic ultrasound combined with microbubbles. [PDF]

Fluids Barriers CNS
van der Panne SA, Koster IZ, Grootemaat AE, van der Wel NN, Ries MG, de Vries HE, van der Weerd L, Strijkers GJ, Bakker ENTP.   +8 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Throwers oblique rotator cuff (TORC) MRI view of the shoulder improves reader confidence for internal impingement abnormalities in overhead throwing athletes. [PDF]

Sci Rep
McDaniel LE, Patel M, Buerba RA, Shah AA, Lederman ES, Lund P.   +5 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Ricin B lectin-like proteins mediate thermotolerance, cell wall integrity, and fungal virulence in <i>Cryptococcus neoformans</i>. [PDF]

Cell Surf
Shu X, Zhang X, Zhao Y, Chen H, Xiong F, Cao C.   +5 more
europepmc   +1 more source

Design and Implementation of High-Capacity DDR3 Micro-Module Based on 3D TSV Advanced Packaging. [PDF]

Micromachines (Basel)
Ji H, Zeng L, Qian H, Tian W, Lin J, Duan Y.   +5 more
europepmc   +1 more source

Next-generation signaling: Powering the future of publications in the <i>Journal of Cell Communication and Signaling</i>. [PDF]

J Cell Commun Signal
Chaqour B.
europepmc   +1 more source

Neuroimaging of the monoaminergic system in Parkinson's disease: A narrative review. [PDF]

Neuroimage Rep
Samanci Y, Tan S, Temel Y, Jahanshahi A.
europepmc   +1 more source