Results 151 to 160 of about 5,505,088 (293)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1. [PDF]

Proc Natl Acad Sci U S A
Vetrano P, Krall K, Martinez L, Traverso E, Morosinotto T, Irwin NAT, Mazor Y, Ramundo S.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Dry discharge-assisted grinding surface quality of RB-SiC

Jin'gangshi yu moliao moju gongcheng
ObjectivesThe imaging quality and optical performance of reaction-bonded silicon carbide (RB-SiC) space mirrors depend heavily on surface integrity during ultra-precision machining. However, the high hardness and brittleness of RB-SiC make it challenging
GAO Haoxuan, HUANG Haojun, LU Yanjun, CHENG Rong, CHEN Fumin   +4 more
doaj  

Feasibility of Ultrashort Echo Time MR Imaging for the Detection of Subclinical Achilles Enthesitis in Psoriasis and Psoriatic Arthritis. [PDF]

Magn Reson Med Sci
Fukuda T, Umezawa Y, Momose M, Asahina A, Ogihara A, Itou R, Kitagawa H, Murata K, Sommer S.   +8 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Microscopic Mechanism of Glass Surface Activation, Annealing and Etching on Glass-Ti/Cu Interfacial Adhesion. [PDF]

Micromachines (Basel)
Shi T, Yang W, Li Q, Yang J, Li Z, Hong H, Zhang Z, Zhang G, Chang AC.   +8 more
europepmc   +1 more source

Interconnections discontinuities in electronic systems and signal integrity faults

, 2001
The paper deals with the influence of discontinuities in interconnecting traces, vias, pads, connectors, parasitics of the IC packages and all other passive interconnecting elements in multi-layer printed-circuit boards (PCB) and multichip modules (MCM ...
Žilka, Zdeněk
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

First Hydration Shell Integrity: Key to Protein Stability. [PDF]

J Am Chem Soc
Wang Z, Tremblay M, Hatzis-Schoch N, Zhu T, Hammes-Schiffer S, Yan ECY.   +5 more
europepmc   +1 more source