Results 191 to 200 of about 44,408 (304)

Spectroscopic Evaluation of AlN/n-Si MIS Structures through Frequency-Driven Dielectric Characterization. [PDF]

ACS Omega
Karaca A, Yıldız DE, Ertuğrul Uyar R, Tataroğlu A.   +3 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity. [PDF]

Proc Natl Acad Sci U S A
Liao J, He Y, Zhang C, Qian Q, Huang Y, Zhang Q, Shen P, Zhou C, Wu M, Chen G.   +9 more
europepmc   +1 more source

A surface-exposed cardiolipin synthase provides an unexpected paradigm for maintaining the Gram-negative outer membrane. [PDF]

Proc Natl Acad Sci U S A
Herrera CM, Demey LM, Ellison CK, Trent MS.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Intestinal epithelial cell-specific deletion of Jak2 disrupts gut homeostasis. [PDF]

Sci Rep
D'Mello B, Rivera D, Rehal S, Pollock-Tahiri E, Li YZ, Dodington D, Wagner KU, Streutker C, Woo M.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Room-Temperature Framework Oxygen Isotope Exchange during Interaction of Water with Hydrophilic Pure-Silica Zeolites Studied Using Nuclear Magnetic resonance Spectroscopy and Neutron Diffraction. [PDF]

J Am Chem Soc
Kelly NL, Stanzione MG, Brako-Amoafo D, Lawrence GB, Rice CM, Wheatley PS, Keys JM, Heard CJ, Fischer HE, Gibbs AS, Ashbrook SE, Morris RE.   +11 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Epithelial cell fusion is required for tissue repair following UV-A irradiation. [PDF]

Proc Natl Acad Sci U S A
Shen M, Mitchell LG, Boer LW, Bischoff LM, Losick VP.   +4 more
europepmc   +1 more source