Results 151 to 160 of about 97,739 (268)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Photonic based Radar: Characterization of 1x4 Mach-Zehnder Demultiplexer

open access: yes, 2012
This work is based on a research activity which aims to implement an optical transceiver for a photonic-assisted fully–digital radar system based on optic miniaturized optical devices both for the optical generation of the radiofrequency (RF) signal and ...
SHAHZAD, UMAR
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Challenges in Signal Processing for Automotive Safety Systems

open access: yes, 2005
The amount of software in general and safety systems inparticular increases rapidly in the automotive industry. The trend is that functionality is decentralized, so new safety functions are distributed to common shared computer hardware, sensors and ...
Gustafsson, Fredrik,
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Associations of Vocal Features, Psychiatric Symptoms, and Cognitive Functions in Schizophrenia

open access: yesNeuropsychiatric Disease and Treatment
Tomoya Natsuyama,1 Enkhmurun Chibaatar,1 Yuko Shibata,2 Naomichi Okamoto,1 John Noel Cruz Victorino,2 Atsuko Ikenouchi,1 Tomohiro Shibata,2 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu ...
Natsuyama T   +7 more
doaj  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

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