Results 181 to 190 of about 6,827,955 (283)

Porcupine‐Quill‐Inspired Shape‐Morphing Biointerfaces Disassemble Biofilms

Advanced Science, EarlyView.
A porcupine‐spine‐inspired dynamic offensive bio‐interface is developed for active biofilm disassembly. By coupling electrically driven nano‐dagger penetration with light‐triggered ROS generation, the surface overcomes the passive limitations of conventional mechano‐bactericidal topographies, achieving near‐complete biofilm eradication, strong ...
Feng Qian, Muqiu Xia, Ziyu Wang, Xinyuan Jia, Jinke Yin, Mengyu Fu, Xue Zhang, Xiao‐Lei Shi, Shiqiang Chen, Ning Wang, Zhi‐Gang Chen   +10 more
wiley   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Lewis Acid‐Catalyzed Strain‐Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole‐Fused Aza‐Bicyclo[3.1.1]Heptanes

Advanced Science, EarlyView.
Bicyclo[1.1.0]butanes undergo a Lewis acid‐catalyzed formal (3 + 3) annulation with indolyl alcohols to furnish indole‐fused aza‐bicyclo[3.1.1]heptanes. Strain‐release‐driven C‐C bond formation, followed by C‐N bond formation via ring expansion, enables the rapid assembly of rigid, sp3‐rich bicyclic architectures under mild reaction conditions ...
Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V. Mane, Chinmoy Kumar Hazra   +4 more
wiley   +1 more source

Interfacial Polarization Dynamics of Nitrile Dipoles in Organic Synaptic Transistors for Acoustic Reservoir Computing

Advanced Science, EarlyView.
Interfacial nitrile dipoles unlock tunable memory in organic synaptic transistors through competing polarization and relaxation. Their finite time dynamics are directly harnessed for acoustic reservoir computing, delivering 97.17% spoken digit recognition, reliable speech emotion and snoring recognition, and an ultralow event energy of only 50 aJ ...
Yutian Liu, Jiale Huang, Haoran Fang, Jichen Zhao, Fan Ye, Bo Huang, Ruibin Liang, Jintao Xu, Fanqi Wang, Mingjun Huang, Zhiming Lin, Shuguang Zhang, Linfeng Lan, Junbiao Peng   +13 more
wiley   +1 more source

Metasurface‐Based Multidimensional Light‐Field Manipulation: From Technologies to Applications

Advanced Science, EarlyView.
Multidimensional metasurfaces enable versatile manipulation of multiple optical degrees of freedom, including phase, amplitude, polarization, wavelength, and orbital angular momentum. This review summarizes their fundamental mechanisms, emerging strategies for multidimensional light‐field control, and key applications in optical computing, imaging ...
Heliang Yin, Shuo Sun, Jiahao Zhang, Jianuo Hu, Yubin Qiao, Liang Chen, Jin Li   +6 more
wiley   +1 more source

Multiscale Interfacial Engineering Enables Robust Reconstituted Wood

Advanced Science, EarlyView.
Conventional adhesives used in wood composites create heterogeneous interfaces that cause stress concentration under humid or aqueous conditions, thereby compromising long‐term stability. A synergistic strategy integrating interfacial reconstruction and water‐induced regeneration transforms heterogeneous interfaces into homogeneous ones with ...
Huizheng Wu, Yi Kong, Liangxian Liu, Yuyan Jiang, Jiahuan He, Haiyu Li, Ming Wei, Dexiu Min, Jian Li, Yanjun Xie, Chi Zhang, Shaoliang Xiao   +11 more
wiley   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

Interface‐Confined Cavitation at an MXene/TiO2 Schottky Heterointerface for Non‐Thermal Juice Preservation

Advanced Science, EarlyView.
This work establishes an MXene/TiO2 Schottky heterointerface for non‐thermal sonocatalysis. Interface‐confined cavitation and dynamic Ti3+/V₀ shuttles drive charge transport and reactive oxygen species (ROS) generation. The platform achieves 3‐log pathogen reduction while retaining heat‐labile nutrients in complex food matrices, redefining sonocatalyst
Xiaoge Wu, Yunxiao Zhu, Nan Qin, Zhaoli Zhang, Qi Zhang, Yang Tao   +5 more
wiley   +1 more source

A CT Lesion Foundation Model for Non‐Invasive Assessment of Hepatocellular Carcinoma Aggressiveness and Prediction of Recurrence Risk

Advanced Science, EarlyView.
A computed tomography lesion foundation model, built by sequential self‐supervised pretraining on generic and hepatocellular carcinoma‐specific lesion images, non‐invasively assesses microvascular invasion and pathological grade from contrast‐enhanced CT and stratifies postoperative recurrence risk.
Wei Xia, Zhehan Shen, Mengsi Li, Jianxin Lu, Ji Xia, Yang Cheng, Wenzheng Li, Shunjie Dong, Lin Deng, Ruokun Li   +9 more
wiley   +1 more source

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

Advanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu, Jindian Li, Xiaoyu Pan, Xiaoping Xu, Xuan Huang, Simin He, Jianping Zhang, Fei Liu, Shaoli Song   +8 more
wiley   +1 more source