Results 81 to 90 of about 3,600,645 (297)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2009 Quarterly; Began with Mar. 31, 2004?; Description based on: Mar. 31, 2004; title from foot of p. 1 (publisher's web site, viewed Nov. 19, 2008).; Latest issue consulted: June 30, 2008 (viewed Nov.
Connecticut Resources Recovery Authority.
core +4 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Recovery of the Starting Times of Delayed Signals
IEEE Signal Processing Letters, 2018 We present a new method to locate the starting points in time of an arbitrary number of (damped) delayed signals. For a finite data sequence, the method permits to first locate the starting point of the component with the longest delay, and then --by iteration-- all the preceding ones.
Luca Perotti +2 more
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Marine Science and EngineeringMud pulse telemetry (MPT) systems are a promising approach to transmitting downhole data to the ground. During transmission, the amplitudes of pressure waves decay exponentially with distance, and the channel is often frequency-selective due to ...
Jingchen Zhang +5 more
doaj +1 more source
IEEE Access, 2019 To study the signal transmission mechanism in the human body, the channel characteristics are generally analyzed by modeling. In current modeling methods, the human body is considered quasi-static and the human tissues isotropic, for simplifying the ...
Shuang Zhang +8 more
doaj +1 more source
Recovery From Alcohol and Other Drug Problems in the U.S. Population: Prevalence, Pathways, and Predictors [PDF]
, 2018 The concept of "recovery" has become the organizing paradigm in many middle and high income countries globally with a goal of orienting services in cost effective ways to help sufferers achieve and maintain long term remission. Despite this focus, little
Hoeppner, Bettina +5 more
core +1 more source