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Cholesterol in signal transduction
Current Opinion in Cell Biology, 2000Membrane cholesterol impinges on signal transduction in several ways, which is highlighted in particular by the Hedgehog signaling pathway. In Hedgehog signaling, cholesterol is important for ligand biogenesis, as well as for signal transduction in receiving cells.
J P, Incardona, S, Eaton
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Regulation of signal transduction
Advances in Enzyme Regulation, 19951. A systematic study is reported on the control of 1-phosphatidylinositol 4-kinase (PI kinase) and PI 4-phosphate 5-kinase (PIP kinase), enzymes of the phosphatidylinositol phosphorylation pathway which leads to the production of second messengers. IP3 and DAG.
G, Weber +5 more
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Oncogenes and Signal Transduction
Hospital Practice, 1993Cancer biologists now have a unified concept to guide their search for specific genetic abnormalities and new therapeutic approaches: The genes and proteins that participate in the conversion of normal into malignant cells are also involved in the key process that converts extracellular signals into intracellular events that culminate in division and ...
A J, Wong, C M, Croce
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Cytokines and signal transduction
Best Practice & Research Clinical Haematology, 2005Many studies have characterized the role of growth factors in multiple myeloma (MM) pathogenesis and have derived novel therapies to improve patient outcome based upon targeting cytokines and their signaling cascades both in the MM cell and in the bone-marrow (BM) microenvironment.
Teru, Hideshima +3 more
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British Medical Bulletin, 1991
Ordered cell proliferation relies on a complex interplay between diverse cell types, interstitial stroma and organ vasculature. At a cellular level the response to growth stimuli is dependent on the bidirectional exchange of information between the cell membrane and nucleus.
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Ordered cell proliferation relies on a complex interplay between diverse cell types, interstitial stroma and organ vasculature. At a cellular level the response to growth stimuli is dependent on the bidirectional exchange of information between the cell membrane and nucleus.
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Journal of Nuclear Cardiology, 2000
Much work remains to be done in elucidating the role of specific signaling pathways first in animal models of cardiac disease and then in clinical settings. Animal studies have begun to implicate specific pathways in the pathogenesis of a variety of cardiac conditions including cardiac hypertrophy, contractile dysfunction, and cardiomyocyte loss ...
K H, Lee +5 more
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Much work remains to be done in elucidating the role of specific signaling pathways first in animal models of cardiac disease and then in clinical settings. Animal studies have begun to implicate specific pathways in the pathogenesis of a variety of cardiac conditions including cardiac hypertrophy, contractile dysfunction, and cardiomyocyte loss ...
K H, Lee +5 more
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Calcium and signal transduction
Biochemistry and Molecular Biology Education, 2008AbstractCell signaling is an essential process in which a variety of external signals, defined as first messengers, are translated inside the cells into specific responses, which are mediated by a less numerous group of second messengers. The exchange of signals became a necessity when the transition from monocellular to pluricellular life brought with
Fedrizzi, Laura +2 more
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Oncogenes and signal transduction
Cell, 1991The purpose of this review is to incorporate recent discoveries into a general biochemical pathway by wich the protein products of the oncogenes send signals from the cell surface to the nucleus .The protein-tyrosine kinase oncogenes will be the primary focus of the review .However, biochemical connections between the protein tyrosine kinases and ...
L C, Cantley +6 more
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Quantitation of signal transduction
The FASEB Journal, 2000ABSTRACT Conventional qualitative approaches to signal transduction provide powerful ways to explore the architecture and function of signaling pathways. However, at the level of the complete system, they do not fully depict the interactions between signaling and metabolic pathways and fail to give a manageable ...
S, Krauss, M D, Brand
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Gibberellin signal transduction
Current Opinion in Plant Biology, 2000Recent studies using biochemical and genetic approaches have identified a number of components, including several negative regulators, of the gibberellin (GA) signal transduction pathway in higher plants. The basal state of GA signaling is likely to be repressive, and the GA signal seems to activate the pathway by de-repression to allow GA-stimulated ...
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