Results 51 to 60 of about 541,244 (307)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Reconstruction Technique of Distorted Sensor Signals With Low-Pass NGD Function

IEEE Access, 2020
This paper develops a new reconstruction technique of undesirable signal distortion generated by sensor electronic circuits. The introduced reconstruction technique is originally realized with unfamiliar low-pass negative group delay (NGD) function.
Blaise Ravelo, Wenceslas Rahajandraibe, Yajian Gan, Fayu Wan, Nour Mohammad Murad, Alexandre Douyere   +5 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Vibration Separation Methodology Compensated by Time-Varying Transfer Function for Fault Diagnosis of Non-Hunting Tooth Planetary Gearbox

Sensors, 2022
Due to planetary movement of planet gears, the vibration signal perceived by a stationary sensor is modulated and difficult to diagnose. This paper proposed a vibration separation methodology compensated by a time-varying transfer function (TVTF-VS ...
Shuiguang Tong, Junjie Li, Feiyun Cong, Zilong Fu, Zheming Tong   +4 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

The wavelet transfer function of a human body–seat system

Journal of Low Frequency Noise, Vibration and Active Control, 2019
In the analysis of vibration systems, classical transfer functions are used. Usually, it is the ratio of Fourier or Laplace transforms. The wavelet transfer function is proposed in this work.
Andrzej Błażejewski, Sebastian Głowiński, Igor Maciejewski   +2 more
doaj   +1 more source

Small Signal Audio Susceptibility Analysis of Flyback Converter With Peak Current Mode Control

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Small signal audio susceptibility of flyback converter with peak currentmode control method is presented by utilizing pwm-switch model in ContinuousConduction Mode (CCM).
Ekrem Çengelci
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Convergence Analysis of EFOP Estimate Based on Frequency Domain Smoothing

Journal of Applied Mathematics, 2013
The classic methods for frequency domain transfer function estimation such as the Empirical Transfer Function Estimate (ETFE) and cross spectral method do not work well when the noise signal is complex.
Yulai Zhang, Kueiming Lo, Yang Su
doaj   +1 more source