Results 131 to 140 of about 9,547,943 (379)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Phytochrome-dependent responsiveness to root-derived cytokinins enables coordinated elongation responses to combined light and nitrate cues

Nature Communications
Plants growing at high densities can detect competitors through changes in the composition of light reflected by neighbours. In response to this far-red-enriched light, plants elicit adaptive shade avoidance responses for light capture, but these need to
Pierre Gautrat, Sara Buti, Andrés Romanowski, Michiel Lammers, Sanne E. A. Matton, Guido Buijs, Ronald Pierik   +6 more
doaj   +1 more source

On Clock Errors and Wireless Time Signals [PDF]

, 1920
R. A. Sampson
openalex   +1 more source

The Fibroblast Growth Factor signaling pathway

Wiley Interdisciplinary Reviews: Developmental Biology, 2015
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs).
D. Ornitz, N. Itoh
semanticscholar   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

mTOR Signaling in Growth, Metabolism, and Disease

Cell, 2017
R. A. Saxton, D. Sabatini
semanticscholar   +2 more sources

Melamine promotes calcium crystal formation in three-dimensional microfluidic device

Scientific Reports, 2019
Melamine, which induces proximal tubular (PT) cell damage has a greater nephrotoxic effect when combined with cyanuric and uric acids; however, it is unknown whether such effect can stimulate calcium phosphate (CaP)/calcium oxalate (CaOx) stone formation.
Farai Gombedza, Sade Evans, Samuel Shin, Eugenia Awuah Boadi, Qian Zhang, Zhihong Nie, Bidhan C. Bandyopadhyay   +6 more
doaj   +1 more source

Submarine signaling: The protection of shipping by a wall of sound and other uses of the submarine telegraph oscillator [PDF]

, 1914
R. F. Blake
openalex   +1 more source

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

A Visual and Photographic Device for Recording Radio Signals [PDF]

, 1921
C. A. Hoxie
openalex   +1 more source