Results 201 to 210 of about 488,795 (269)

MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and Are Clinically Relevant across Central Nervous System Disorders. [PDF]

Cancer Res
Alvaro-Espinosa L, Marquez-Galera A, Priego N, García-Calvo V, Perea-García M, Hernandez-Oliver C, Retana D, Sanchez O, de Pablos-Aragoneses A, García-Gómez P, Graña-Castro O, Lapuente-Santana Ó, Serrano-Ron L, Al-Shahrour F, Cayuela López A, Peset I, Megías D, Ola M, Varešlija D, Young LS, Martí-Mateos Y, Enríquez JA, Hernández-Encinas E, Blanco-Aparicio C, Soengas MS, Bernhagen J, Antón-Fernández A, Ávila J, Marchena MA, Torres M, de Castro F, Márquez-Ropero M, Sierra A, Lopez-Atalaya JP, RENACER Group, Valiente M.   +35 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Decoding isonicotinylation-associated patterns in neutrophil chronic obstructive pulmonary disease: evidence from integrative bioinformatic-driven multi-omics and <i>in vitro</i> validation. [PDF]

Front Physiol
Wang Z, Li Y, Zhou M, Xiang M, Lin J.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Comprehensive analysis of mutational signatures and corresponding driver genes in cervical cancer from Xinjiang. [PDF]

Biochem Biophys Rep
Chen C, Zhao W, Guo M, Wang W, Ma J, Niyazi M, Zhu K.   +6 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A PTPRO-Related Five-Gene Blood Transcriptional Signature with Diagnostic Potential for Tuberculosis. [PDF]

Biomedicines
Wu F, Huang R, Lin Y, Zhu X, Li Y, Dai H, Zhou X, Fang F, Liang Y, Xu T, Song C, Li W, Wang X, Chang X, Wang H, Wang T, Lv J, Qian Z.   +17 more
europepmc   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Comprehensive analysis to develop a stromal senescence-associated gene signature for predicting hepatocellular carcinoma. [PDF]

Transl Cancer Res
Lu J, Zhang Z, Yuan W, Zhang Y.
europepmc   +1 more source

Integration of single-cell regulon atlas and bulk RNA-seq for individualized prognostic prediction in stomach adenocarcinoma. [PDF]

iScience
Zhang A, Li Z, Jiang X, Li Y, Zhang M, Ding Y.   +5 more
europepmc   +1 more source