Results 201 to 210 of about 835,228 (309)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Integrative single-cell and bulk transcriptomic analyses identify a microglia-associated NAGLU signature linked to disulfidptosis-associated transcriptional patterns after spinal cord injury. [PDF]

Front Immunol
Liu X, Hu J, Zhu W, Shi G, Kang P.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

A six-metabolite signature characterizes metabolically unhealthy obesity and reveals hidden metabolic risk within metabolically healthy obesity. [PDF]

Front Endocrinol (Lausanne)
Gao P, Liang M, Tang B, Li J, Mao R, Feng Z, Zhang T, Liu Y.   +7 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Minimally Invasive Aortic Regurgitation Surgery

JACC: Basic to Translational Science
Jinyun Zhu, PhD, MD, Chen Gao, PhD, Yibin Wang, PhD   +2 more
doaj   +1 more source

Genome-Wide Analysis of Alternative Splicing Identifies a Prognostic Signature in ER-Positive Breast Cancer. [PDF]

Genes (Basel)
Basudan AM, Alshuweishi Y, AlSudais H, Alfhili MA.   +3 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Integrated transcriptomic and lipidomic analyses reveal altered lipid homeostasis in mutant FUS P525L astrocytes from HiPSCs

Journal of Translational Medicine
Yingli Zhu, Jingxiu Huang, Katrien Neyrinck, Mingkang Liu, Tianyi Yang, Karan Ahuja, Yoke Chin Chai   +6 more
doaj   +1 more source

Identification and validation of a previously missed mutational signature in colorectal cancer. [PDF]

Nat Commun
Kazachkova M, Otlu B, Díaz-Gay M, Abbasi A, Moody S, Jiang Z, Perdomo S, Wedge DC, Brennan P, Stratton MR, Alexandrov LB.   +10 more
europepmc   +1 more source