Results 21 to 30 of about 61,304 (244)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

D’un style scientifique dans certaines revues d’avant-garde (BLAST, The Signature, The Egoist, 1914-1915) [PDF]

Etudes de stylistique anglaise, 2011
A certains moments de l’histoire culturelle, l’artificielle frontiere entre style litteraire et langage scientifique tombe et laisse la place a un style hybride, propre a la mise en place d’une litterature-recherche. En Angleterre, les annees 1914-1915 sont un de ces moments.
openaire   +2 more sources

Contribution du Cirad-Emvt à l'appui scientifique du projet FSP "concertation agricole et structuration des filières en Ouganda" : rapport de mission en Ouganda du 15 au 22 mars 2003 [PDF]

, 2003
Présent en Ouganda depuis 1998, le Programme Productions Animales (CIRAD-EMVT) n'avait pour l'instant oeuvré qu'au travers de missions courtes et d'appui à des stagiaires et un CSN. Le démarrage du FSP "concertation agricole et soutien aux filières (CASF)
Faye, Bernard, Grimaud, Patrice
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The spectral variability and magnetic field characteristics of the Of?p star HD 148937 [PDF]

, 2011
We report magnetic and spectroscopic observations and modeling of the Of?p star HD 148937 within the context of the MiMeS LP at the CFHT. Thirty-two high signal-to-noise ratio circularly polarised (Stokes V) spectra and 13 unpolarised (Stokes I) spectra ...
Balona, C. J. Evans, C. P. Folsom, Donati, Donati, Dufour, F. Martins, Fairall, Folsom, G. A. Wade, G. Gräfener, Harmanec, Hillier, Howarth, Howath, Hubrig, Hubrig, I. D. Howarth, J. Grunhut, J. S. Vink, Kaufer, Lanz, Martins, Meynet, Müller, N. R. Walborn, Nazé, Nazé, Nazé, Nazé, Petit, R. H. D. Townsend, Rees, S. Bagnulo, Seaton, Ud-Doula, V. Petit, van Genderen, van Genderen, Vink, Wade, Wade, Walborn, Walborn, Y. Nazé   +44 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

3D-melting features of the irreversibility line in overdoped Bi$_2$Sr$_2$CuO$_6$ at ultra-low temperature and high magnetic field

, 1999
We have measured the irreversible magnetization of an overdoped Bi$_2$Sr$_2$CuO$_6$ single crystal up to B=28 T and down to T=60 mK, and extracted the irreversibility line $B_{\rm irr}(T)$: the data can be interpreted in the whole temperature range as a ...
Gonnelli, R. S., Jansen, A. G. M., Morello, A., Vedeneev, S. I.   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Intermittency of velocity time increments in turbulence [PDF]

, 2005
We analyze the statistics of turbulent velocity fluctuations in the time domain. Three cases are computed numerically and compared: (i) the time traces of Lagrangian fluid particles in a (3D) turbulent flow (referred to as the "dynamic" case); (ii) the ...
A. Arnéodo, E. Lévêque, G. Ruiz-Chavarria, H. Tennekes, H. Tennekes, J.-F. Pinton, J. M. Ottino, L. Chevillard, M. S. Borgas, N. Mordant, P. K. Yeung, R. Benzi, S. G. Roux, U. Frisch   +13 more
core   +5 more sources

Unusual Swelling Behavior of Hydrogels Modified with Spiropyran as Appendage or Crosslinker

Advanced Functional Materials, EarlyView.
Not so innocent after all—spiropyran crosslinkers in methylenebisacrylamide‐crosslinked poly(acrylamide‐co‐acrylic acid) hydrogels increase crosslinking density, but also, counterintuitively, increase swelling. Charge complexation, cooperative chemo‐mechanical effects, and aggregation may explain these observations.
Michael M. Lerch, Ankita Shastri, Thomas B. H. Schroeder, Amos Meeks, Shucong Li, Anna V. Shneidman, Michael Aizenberg, Joanna Aizenberg   +7 more
wiley   +1 more source