Results 171 to 180 of about 70,726 (237)

Cholinergic modulation mediates attentional mechanism to enhance coherence between cortical layers in macaque V1 and V4. [PDF]

Sci Rep
Sajedin A, FallahTaherpazir M, Menhaj MB.   +2 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Tactile exploration and imagery elicit distinct neural dynamics in the parietal cortical network. [PDF]

Front Neurosci
Zhang Q, Yang Y, Wang Z, Zhou J, Gao R, Yang X, Li S, Yu T, Zhou J, Wang C.   +9 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Smooth dynamic <i>T₂ ^*</i> mapping in fMRI based on a novel, total variation-minimizing algorithm for efficient multi-echo BOLD time series denoising with high signal-to-noise and contrast-to-noise ratios. [PDF]

Front Neurosci
Michálek J, Mikl M.
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

COVID-19 global risk evaluation: rankings, reducing surveillance bias, and infodemic. [PDF]

Front Public Health
Michalak MP, Węglińska E, Kulawik A, Cordes J, Lupa M, Leśniak A.   +5 more
europepmc   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Revealing the U-shaped nonlinear relationship between lipid accumulation product levels and cardiovascular disease risk using the large CHARLS cohort study in China. [PDF]

BMC Public Health
Zhang YB, Chen C, Zheng T, Sun G.
europepmc   +1 more source

Flight training and alterations in cortical characteristics. [PDF]

Front Hum Neurosci
Chen X, Chu Q, Wang H, Tan X, Duan M, Luo C.   +5 more
europepmc   +1 more source