Results 111 to 120 of about 2,598,126 (331)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
A remark on eigen values of signed graph
Journal of Applied Mathematics, Statistics and Informatics, 2019 In this paper we present some results using eigen values of signed graph. This precipitate to find the determinant of signed graph using the number of vertices.
B. Prashanth, K. Naik, K. R. Rajanna
semanticscholar +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Restrained domination in signed graphs
Acta Universitatis Sapientiae: Mathematica, 2020 A signed graph Σ is a graph with positive or negative signs attatched to each of its edges. A signed graph Σ is balanced if each of its cycles has an even number of negative edges.
Mathias Anisha Jean +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Perturbations in a Signed Graph and its Index
Discussiones Mathematicae Graph Theory, 2018 In this paper we consider the behaviour of the largest eigenvalue (also called the index) of signed graphs under small perturbations like adding a vertex, adding an edge or changing the sign of an edge.
Z. Stanić
semanticscholar +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
On the existence of non-golden signed graphs
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2018 A signed graph is a pair Γ=(G,σ), where G=(V(G), E(G)) is a graph and σ: E(G) → {+1, -1} is the sign function on the edges of G. For a signed graph we consider the least eigenvalue λ(Γ) of the Laplacian matrix defined as L(Γ)=D(G)-A(Γ), where D(G) is the
Maurizio Brunetti
doaj +1 more source