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What Is the Significance of a Significant TDT?

Human Heredity, 2005
This note summarizes the development of the transmission/disequilibrium test (TDT). The initial purpose of the TDT procedure was to test for linkage between a genetic marker and a disease susceptibility locus when an association had been found between the two. An association between disease and marker had sometimes been taken to imply linkage.
Warren J, Ewens, Richard S, Spielman
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The OR and significance

The Pavlovian Journal of Biological Science, 1990
A brief review was conducted of past and current research and theory as well as future implications of the problem of significance and the OR. Research and theory in the field is judged to be at a choice point: advance to interesting and important problems integrated with biobehavioral research or enter a blind alley of pseudo-problems derived from ...
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Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance.

Trends in Cancer, 2020
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop produced from 'back-splicing' of primary transcripts, conferring on them ...
Jiao Li   +4 more
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Is Statistical Significance Always Significant?

Nutrition in Clinical Practice, 2005
One way in which we learn new information is to read the medical literature. Whether or not we do primary research, it is important to be able to read literature in a critical fashion. A seemingly simple concept in reading is to interpret p values. For most of us, if we find a p value that is <.05, we take the conclusion to heart and quote it at ...
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Risk significance and safety significance

Reliability Engineering & System Safety, 2001
Abstract Existing measures of the risk significance of elements of risk models (such as the Fussell–Vesely, or ‘F–V’, importance of basic events) are based on the properties of cut sets containing the element. A measure of safety significance (prevention worth, or PW ) is proposed, based on the properties of path sets containing the element.
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The importance of significance and the significance of importance

Postgraduate Medicine, 1979
This article has attempted to illustrate the following principles of statistical significance. 1. An investigator must state the hypothesis to be tested beforehand, so that a null hypothesis can be constructed and validly tested using standard statistical techniques. 2. A statistically significant difference does not prove that a difference exists.
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The significance of significant figures

Journal of Chemical Education, 1967
This paper is an attempt to clarify some of our ideas about numerical data, measurements, mathematical operations, and significant figures.
Richard C. Pinkerton, Chester E. Gleit
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Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.

Journal of Consulting and Clinical Psychology, 1991
N. S. Jacobson, P. Truax
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The Significance of Statistical Significance:

Law & Social Inquiry, 2009
This essay reviews The Cult of Statistical Significance: How the Standard Error Costs Us Jobs, Justice, and Lives, by Stephen T. Ziliak and Deirdre N. McCloskey. The book's core message is that statistical significance should not be equated with substantive significance and that empirical researchers should convey more information about
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