Significant functional difference between TNFAIP3 truncation and missense mutants
Leire Escudero-Ibarz +2 more
doaj +1 more source
Minghui Cheng,1,* Yiju Wang,2,* Shusen Liu,3 Shiyu Zhang,1 Changjiang Wang,1 Hao Sun,1 Hui Xie,1 Yinan Xu4 1School of Clinical Medicine, Jining Medical University, Jining, 272013, People’s Republic of China; 2Department of Psychiatry ...
Cheng M +7 more
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Are glomerular volume differences between type 1 and type 2 diabetic patients pathologically significant? [PDF]
Kathryn White, S. M. Marshall, RW Bilous
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Fellow Efficiency During Anterior Cruciate Ligament Reconstruction Improves Over Time, Yet Is Less Than Experienced Physician Assistant But With No Significant Difference in Patient-Reported Outcomes. [PDF]
Hazzard SM +3 more
europepmc +1 more source
“There are significant differences…”: The secret life of existential there in academic writing [PDF]
Feng Jiang, Ken Hyland
openalex +1 more source
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source

