Results 191 to 200 of about 12,031,704 (340)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

No significant differences in postoperative clinical outcomes evolution after fresh osteochondral allograft transplantation of the knee between patients with pathological and non‐pathological scores regarding anxiety, depression, kinesiophobia and catastrophizing factors [PDF]

Pablo Eduardo Gelber, Eduard Ramírez‐Bermejo, Anna Castellà‐Pujol, Aránzazu González Osuna, Óscar Fariñas   +4 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

No significant difference in skin contamination during anterior cruciate ligament reconstruction with and without preoperative skin cleaning. [PDF]

Knee Surg Sports Traumatol Arthrosc
Bartek B, Völkner A, Oehme S, Fahy S, Winkler T, Jung T.   +5 more
europepmc   +1 more source

No Significant Difference Between Intramedullary and Extramedullary Button Fixation for Distal Biceps Brachii Tendon Rupture After Cyclic Loading in a Cadaver Model. [PDF]

Arthrosc Sports Med Rehabil, 2021
Majumdar A, Salas C, Chavez W, Bankhead C, Sapradit TJ, Mercer D, Wascher DC, Richter DL.   +7 more
europepmc   +1 more source

Significant differences in struvite and cystine stone frequency seen among Chinese nephrolithiasis patients living in North America compared to those living in China [PDF]

, 2016
Thomas Chi, Manint Usawachintachit, Pauline Filippou, David Bayne, Weiguo Hu, Helena Chang, Lei Xia, Qi Chen, Wei Xue, Hui He, Qingzhi Long, Olga Arsovska, Eric N. Taylor, Ryan F. Paterson, Roger L. Sur, Ben H. Chew, Marshall L. Stoller, Jianxing Li   +17 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Significant difference between sirolimus and paclitaxel nanoparticles in anti-proliferation effect in normoxia and hypoxia: The basis of better selection of atherosclerosis treatment. [PDF]

Bioact Mater, 2021
Chen Y, Zeng Y, Zhu X, Miao L, Liang X, Duan J, Li H, Tian X, Pang L, Wei Y, Yang J.   +10 more
europepmc   +1 more source

Assessing Hemodynamically Significant CAD by Difference in Contrast Opacification of CT Angiograms

, 2016
James K. Min
openalex   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source