Results 241 to 250 of about 12,031,704 (340)
In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni +14 morewiley +1 more sourceNo Significant Difference in Viral Load Between Vaccinated and Unvaccinated, Asymptomatic and Symptomatic Groups When Infected with SARS-CoV-2 Delta Variant
, 2021 Acharya CB, Schrom J, Mitchell AM, Coil DA, Marquez C, Rojas S, Wang CY, Liu J, Pilarowski G, Solis L, Georgian E, Petersen M, DeRisi J, Michelmore R, Havlir D. +14 moreeuropepmc +1 more sourceInhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceEffect of compost and chemical fertilizers on microbial biomass phosphorus. (T1: control; T2: 100% RDF; T3: enriched compost; T4: 100% RDF + enriched compost; T5: 50% RDF + enriched compost). * The least significant difference test for separation of means indicates that means that are separated by the same letter are not significantly distinct at P = 0.05.
Dilkhush Meena (21473985), Murli Dhar Meena (18864501), Satendra Singh Sengar (21473988), Vidhya Nand Mishra (21473991), Anup Kumar (1391461), Mohan Lal Lakhera (21473994), Mohan Lal Dotaniya (9727737), Mukesh Kumar Meena (11287133), Sujith Kumar (21473997), Bheeru Lal Meena (18864513), Ram Swaroop Jat (18864504), Lalit Krishan Meena (21474000), Mukesh Prajapat (21474003), Hari Singh Meena (18864510), Avijit Ghosh (1428496), Vasudev Meena (14312365), Pramod Kumar Rai (18864516), Parvender Sheoran (14703865), Vijay Singh Meena (20564213) +18 moreopenalex +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceSubgroup analysis of concentrations of neutral lipids (pmol/mL) which showed significant differences between BMI groups.
Yoo Ra Ko (21417209), Min Kyoung Kim (1871251), Ji Won Kim (566654), E. Jung Han (12206141), Se Jeong Kim (7145381), Jae Kyun Park (17436951), So Yeon Ahn (7847489), Minseo Lee (17453912), Surim Oh (21417212), Sohyun Hwang (224656), Donghyeon Kim (630883), Hyunjung Jade Lim (460760), Woo Sik Lee (7550063) +12 moreopenalex +1 more source
