Results 301 to 310 of about 33,233,550 (381)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

RETRACTION: lncRNA‐PDPK2P Promotes Hepatocellular Carcinoma Progression Through the PDK1/AKT/Caspase 3 Pathway

Molecular Oncology, EarlyView.
RETRACTION: W. Pan, W. Li, J. Zhao, Z. Huang, J. Zhao, S. Chen, C. Wang, Y. Xue, F. Huang, Q. Fang, J. Wang, D. Brand, and S. G. Zheng, “lncRNA‐PDPK2P Promotes Hepatocellular Carcinoma Progression Through the PDK1/AKT/Caspase 3 Pathway,” Molecular Oncology 13, no. 10 (2019): 2246–2258, https://doi.org/10.1002/1878-0261.12553.
wiley   +1 more source

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Reversible data hiding scheme based on significant‐bit‐difference expansion

IET Image Processing, 2017
This study presents a lossless robust data hiding scheme based on significance-bit-difference expansion. The original cover image can be recovered without any distortion after the hidden data have been extracted if the stego image remains intact, on the ...
Jonathan P Piccini, Weiqing Wang, Junyong Ye   +2 more
exaly   +2 more sources

Configurational Isomers Induced Significant Difference in All‐Polymer Solar Cells

Advanced Functional Materials, 2021
The design of polymer acceptors plays an essential role in the performance of all‐polymer solar cells. Recently, the strategy of polymerized small molecules has achieved great success, but most polymers are synthesized from the mixed monomers, which ...
Hengtao Wang, Huirong Chen, Wei-Wei Xie, Hanjian Lai, Tingxing Zhao, Yulin Zhu, Lin Chen, Chunxian Ke, Nan Zheng, Feng He   +9 more
semanticscholar   +1 more source

The significance of 'no significant difference'

Acta Radiologica, 1990
It is generally accepted that patients experience less discomfort with low osmolality contrast media (LOM) than with high osmolar media (HOM). Hard statistical facts from so called ‘high quality’ controlled trials, proving that more significant reactions such as vomiting, hives, urticaria or anaphylactic complications also are less common with LOM are,
B. Jacobsson, J. Brismar
openaire   +3 more sources

Effective and Noneffective Recombination Center Defects in Cu2ZnSnS4: Significant Difference in Carrier Capture Cross Sections

Chemistry of Materials, 2019
By combining the electron–phonon coupling effect and the static coupling formalism, we calculate, through the first-principles methods, the carrier capture cross sections of the three possible nonr...
Ji-Qiang Li, Zhen‐Kun Yuan, Shiyou Chen, X. Gong, Suhuai Wei   +4 more
semanticscholar   +1 more source

Significant Difference in Semiconducting Properties of Isomeric All-Acceptor Polymers Synthesized via Direct Arylation Polycondensation.

Angewandte Chemie, 2019
All-acceptor polymers have been of significant fundamental and technical interests. However, their challenging synthesis by Stille or Suzuki polycondensations has prevented the development and understanding of such polymers.
Yang Wang, Tsukasa Hasegawa, Hidetoshi Matsumoto, T. Michinobu   +3 more
semanticscholar   +1 more source

Reusing the Past Difference Vectors in Differential Evolution—A Simple But Significant Improvement

IEEE Transactions on Cybernetics, 2020
Differential evolution (DE) has established itself as a simple but efficient population-based, nonconvex optimization algorithm for continuous search spaces.
Arka Ghosh, Swagatam Das, A. Das, Liang Gao   +3 more
semanticscholar   +1 more source

Significant difference in the dynamics between strong and fragile glass formers.

Physical Review E, 2016
Glass-forming liquids are often classified into strong glass formers with nearly Arrhenius behavior and fragile ones with super-Arrhenius behavior.
A. Furukawa, Hajime Tanaka
semanticscholar   +1 more source