Results 171 to 180 of about 35,832 (220)
Journal of Controlled Release, 2017 The practice of treating PAH patients with oral or intravenous sildenafil suffers from the limitations of short dosing intervals, peripheral vasodilation, unwanted side effects, and restricted use in pediatric patients.
Jahidur Rashid +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Journal of Controlled Release, 2019
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary ...
Hend I. Shahin +8 more
semanticscholar +1 more source
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary ...
Hend I. Shahin +8 more
semanticscholar +1 more source
Sildenafil and Cardioprotection
Current Pharmaceutical Design, 2013The phosphodiesterese-5 (PDE5) inhibitors, including sildenafil (Viagra™), vardenafil (Levitra™), tadalafil (Cialis™) and avanafil (Stendra™) have been developed for the treatment of erectile dysfunction. Moreover, sildenafil and tadalafil have been approved for the management of pulmonary arterial hypertension.
openaire +2 more sources
Current Opinion in Urology, 2000
Sildenafil has an excellent safety record in its clinical trials but there have been reports of deaths associated with its usage now that it is in widespread clinical use. Many of these deaths are clearly unrelated to the drug and some may be related to usage where there are clear contradictions to its use.
openaire +2 more sources
Sildenafil has an excellent safety record in its clinical trials but there have been reports of deaths associated with its usage now that it is in widespread clinical use. Many of these deaths are clearly unrelated to the drug and some may be related to usage where there are clear contradictions to its use.
openaire +2 more sources
Sildenafil treatment of vascular dementia in aged rats.
Neurochemistry International, 2019BACKGROUND and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white ...
P. Venkat +7 more
semanticscholar +1 more source
Food and Chemical Toxicology, 2018
The present study was designed to investigate the potential protective effects of diosmin (DS) and/or sildenafil against bile duct ligation (BDL). In order to achieve this goal, BDL was performed to induce liver cirrhosis, DS (100 mg/kg/day, p.o.) and ...
Fares E. M. Ali +4 more
semanticscholar +1 more source
The present study was designed to investigate the potential protective effects of diosmin (DS) and/or sildenafil against bile duct ligation (BDL). In order to achieve this goal, BDL was performed to induce liver cirrhosis, DS (100 mg/kg/day, p.o.) and ...
Fares E. M. Ali +4 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications - BBRC, 2018
To understand the molecular mechanisms underlying the beneficial effects of sildenafil in animal models of neurological disorders, we investigated the effects of sildenafil on the mitochondrial toxicity induced by β-amyloid (Aβ) peptide.
Yonghae Son, Koanhoi Kim, Hyok-rae Cho
semanticscholar +1 more source
To understand the molecular mechanisms underlying the beneficial effects of sildenafil in animal models of neurological disorders, we investigated the effects of sildenafil on the mitochondrial toxicity induced by β-amyloid (Aβ) peptide.
Yonghae Son, Koanhoi Kim, Hyok-rae Cho
semanticscholar +1 more source