Results 191 to 200 of about 229,119 (301)

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda   +5 more
wiley   +1 more source

Alternative Polyadenylation Drives Runaway Pro‐Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression

open access: yesCell Proliferation, EarlyView.
APA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Jing Zhang   +6 more
wiley   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

open access: yesCell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu   +7 more
wiley   +1 more source

Insects and Survival: A Review of Primary and Secondary Defense Strategies

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
Based on a review of three decades of literature, insect defense mechanisms are classified into primary (I) and secondary (II) mechanisms of behavioral, morphological, and chemical nature. These mechanisms have been recorded in 22 (I) and 20 (II) orders, respectively.
Lucas Fernandes Silva   +3 more
wiley   +1 more source

The Heart of Silk Road "Xinjiang," Its Genetic Portray, and Forensic Parameters Inferred From Autosomal STRs.

open access: yesFront Genet, 2021
Adnan A   +6 more
europepmc   +1 more source

Nutritional composition of pollen stores in managed bees across European agro‐ecosystems reveals species‐specific differences but limited pesticide effects

open access: yesEcological Entomology, EarlyView.
In the pollen stores of three bee species deployed across 128 European sites, bumble bees harboured lower lipid content and higher protein‐to‐lipid ratios than honey bees and mason bees. Toxicity‐weighted pesticide risk did not alter protein‐to‐lipid ratios, but higher risk was associated with reduced protein and lipid content in the pollen stores of ...
Antoine Gekière   +34 more
wiley   +1 more source

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