Results 91 to 100 of about 2,085,685 (309)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Improved photoetching fabrication method [PDF]

, 1972
Photoetching method producing well-defined lines with minimum undercutting was developed for etching coolant passages in nickel sheet. Phosphate coating is applied over conventional silver plate maskant and phosphoric acid solution is used to remove ...
Kistler, C. L.
core   +1 more source

Migration pattern of silver eel (Anguilla anguilla, L.) in an obstructed river system. [PDF]

, 2008
The downstream migration of European silver eels in the River Frémur was examined to determine the potential effects of the numerous migration barriers that exist on waterways in western France.
Acou, Acou, Acou, Acou, Acou, Acou, Baisez, Behrmann-Godel, Berg, Boubée, Boubée, Boëtius, Budy, Chadwick, Congleton, Cullen, Deelder, Durif, Durif, Durif, Escofier, Euston, Feunteun, Feunteun, Feunteun, Feunteun, Ficke, Frost, Gosset, Hansen, Haraldstad, Haro, Haro, Holmgren, Hvidsten, Jonsson, Laffaille, Larinier, Lee, Legault, Lobon-Cervia, Lowe, Naismith, Olivereau, Pankhurst, Plumb, Robinet, Ryan, Schmidt, Sokal, Tesch, Todd, Travade, van den Thillart, van Ginneken, van Ginneken, van Ginneken, Vøllestad, Vøllestad, Watene, White, Wickström, Zaugg   +62 more
core   +3 more sources

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Silver as Anode in Cryolite—Alumina-Based Melts [PDF]

, 2007
The anodic behaviour of silver was investigated in cryolite—alumina-based melt. Silver has a lower melting point (ca. 960◦C) than the other metals considered as possible inert materials for aluminium electrolysis.
Cassayre, Laurent, Chamelot, Pierre, Kucharik, Marian, Taxil, Pierre   +3 more
core   +2 more sources

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Study design considerations to assess the impact of potential drug–drug interactions in first‐in‐human studies in oncology drug development

Clinical and Translational Science, 2023
Sriram Subramaniam, Stacy S. Shord, Ruby Leong, Kelly Norsworthy, Atiqur Rahman, Brian Booth, Olanrewaju Okusanya   +6 more
doaj   +1 more source

First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge

mBio
Monoclonal antibodies to SARS-CoV-2 can offer prophylactic and therapeutic protection against severe disease, with particular utility for immunosuppressed and vulnerable populations.
Vincent Dussupt, Jaime L. Jensen, Paul V. Thomas, Letzibeth Mendez-Rivera, Kerri G. Lal, Michelle Zemil McCrea, Isabella Swafford, Joana Hernandez, Rajeshwer S. Sankhala, Mekhala Rao, Juhi Arora, Agnes Hajduczki, Ningbo Jian, Phyllis A. Rees, Indica Showell-De Leon, Gabriel Smith, Lauren Smith, Diana Wasson, Annika Schmid, I-Ting Teng, Tongqing Zhou, Peter D. Kwong, Jeffrey R. Currier, William W. Reiley, Dominic Paquin-Proulx, Victoria R. Polonis, Natalie D. Collins, Nelson L. Michael, M. Gordon Joyce, Shelly J. Krebs   +29 more
doaj   +1 more source

Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains

mBio, 2019
GII.4 noroviruses are a major cause of acute gastroenteritis. Their dominance has been partially explained by the continuous emergence of antigenically distinct variants.
Kentaro Tohma, Cara J. Lepore, Yamei Gao, Lauren A. Ford-Siltz, Gabriel I. Parra   +4 more
doaj   +1 more source

Minimally Clinically Important Difference of the Clinical Assessment Scale in Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The Clinical Assessment Scale in Autoimmune Encephalitis (CASE) tracks disease severity in autoimmune encephalitis (AE), but no threshold for significant change exists. We aimed to determine the minimally clinically important difference (MCID) for CASE.
Yihui Goh, Yoon Hee Shin, Soo Hyun Ahn, Su Yee Mon, Soo Jean Shin, Woo‐Jin Lee, Yoonhyuk Jang, Myoung‐Jin Jang, Soon‐Tae Lee   +8 more
wiley   +1 more source