Results 171 to 180 of about 448,081 (264)

Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder. [PDF]

Psychol Med
Wu Y, Xu J, Wang H, Shen Y, Zhai Y, Lei M, Zhang Z, Wu Q, An Q, Cai W, Su L, Peng Y, Zhang Q, Liu F.   +13 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

HKD-CPI: high-order knowledge distillation enhanced inductive compound-protein interaction prediction. [PDF]

Bioinformatics
He Z, Liu X, Jiang Y, Xu J, Lin Y, Jin S, Wei L, Wang Y.   +7 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Study on the adaptability of multilayer subway network under sudden large passenger flow disturbances. [PDF]

PLoS One
Lin NN, Yuan HW, Huang HT, Liu ZG.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Semantic convergence in culturally loaded text translation by Large Language Models: a cross-model empirical analysis of English translations of <i>The Four Books</i>. [PDF]

Front Psychol
Wan Q, Yu Q.
europepmc   +1 more source

Retrieval of Similar Time Series with Similarity Degree of Linguistic Expressions

Proceedings of the Fuzzy System Symposium, 2011
Takahashi, Katsutoshi, Umano, Motohide
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Canonical Pathways Rewiring in Alzheimer's Disease. [PDF]

Int J Mol Sci
Pinta-Castro A, Michel-Ureña G, Pérez-González AP, De Anda-Jáuregui G, Hernández-Lemus E.   +4 more
europepmc   +1 more source