Results 181 to 190 of about 1,583,050 (329)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Similarity measure for intuitionistic fuzzy sets and its applications in pattern recognition and multimodal medical image fusion. [PDF]

Sci Rep
Patel A, Gupta D, Gopalakrishnan EA, Sasidharan D, Sowmya V, Zakariah M, Almazyad AS.   +6 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A parametric similarity measure for neutrosophic set and its applications in energy production. [PDF]

Heliyon
Liu P, Azeem M, Sarfraz M, Swaray S, Almohsen B.   +4 more
europepmc   +1 more source

VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder. [PDF]

Molecules, 2020
Samanta S, O'Hagan S, Swainston N, Roberts TJ, Kell DB.   +4 more
europepmc   +1 more source

Application Of A Similarity Measure For Graphs To Web-Based Document Structures

, 2007
Matthias Dehmer, Frank Emmert‐Streib, Alexander Mehler, Jürgen Kilian, Max Mühlhäuser   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Hidden Markov model-based similarity measure (HMM-SM) for gait quality assessment of lower-limb prosthetic users using inertial sensor signals. [PDF]

J Neuroeng Rehabil
Ng G, Andrysek J.
europepmc   +1 more source

Anomaly Detection in EEG Signals: A Case Study on Similarity Measure. [PDF]

Comput Intell Neurosci, 2020
Chen G, Lu G, Xie Z, Shang W.
europepmc   +1 more source

Improved Cosine Similarity Measures Of Simplified Intuitionistic Sets For Medicine Diagnoses

, 2015
Jun Je
openalex   +1 more source