Results 231 to 240 of about 1,583,595 (288)
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
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2004
Molecular similarity is a pervasive concept in chemistry. It is essential to many aspects of chemical reasoning and analysis and is perhaps the fundamental assumption underlying medicinal chemistry. Dissimilarity, the complement of similarity, also plays a major role in a growing number of applications of molecular diversity in combinatorial chemistry,
Gerald M, Maggiora +1 more
openaire +3 more sources
Molecular similarity is a pervasive concept in chemistry. It is essential to many aspects of chemical reasoning and analysis and is perhaps the fundamental assumption underlying medicinal chemistry. Dissimilarity, the complement of similarity, also plays a major role in a growing number of applications of molecular diversity in combinatorial chemistry,
Gerald M, Maggiora +1 more
openaire +3 more sources
IEEE Transactions on Pattern Analysis and Machine Intelligence, 1999
With complex multimedia data, we see the emergence of database systems in which the fundamental operation is similarity assessment. Before database issues can be addressed, it is necessary to give a definition of similarity as an operation. We develop a similarity measure, based on fuzzy logic, that exhibits several features that match experimental ...
S. Santini, R. Jain
openaire +1 more source
With complex multimedia data, we see the emergence of database systems in which the fundamental operation is similarity assessment. Before database issues can be addressed, it is necessary to give a definition of similarity as an operation. We develop a similarity measure, based on fuzzy logic, that exhibits several features that match experimental ...
S. Santini, R. Jain
openaire +1 more source
Fuzzy similarity measures and measurement theory
2019 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE), 2019We consider objects associated with a fuzzy set-based representation. By using a classic method of measurement introduced by Tversky, we establish necessary and sufficient conditions for the existence of a particular class of fuzzy similarity measures, agreeing with an ordering relation among pairs of objects which express the idea that two objects are
Coletti, Giulianella +1 more
openaire +2 more sources
Neural Processing Letters, 1997
This paper concerns with the ART1 (Adaptive Resonance Theory 1) in Neural Network. Important features of ART1 are similarity measure (criterion), vigilance parameter (r), and their function to classify the input patterns. Experimental results show that the similarity measure as designed originally does not increase the number of categories with the ...
Ei Ei Khin +2 more
openaire +1 more source
This paper concerns with the ART1 (Adaptive Resonance Theory 1) in Neural Network. Important features of ART1 are similarity measure (criterion), vigilance parameter (r), and their function to classify the input patterns. Experimental results show that the similarity measure as designed originally does not increase the number of categories with the ...
Ei Ei Khin +2 more
openaire +1 more source
KWSim: Concepts Similarity Measure.
2008The comparison of manually annotated medical images can be done using the comparison of keywords in a lexical way or using the existing medical thesauri to calculate semantic similarity. In this paper, first we introduce the KWSim measure, a fully automated technique of measuring semantic similarity by mapping concepts(keywords) to different medical ...
Matar, Youssef +2 more
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Evaluating similarity measures
Proceedings of the eleventh ACM SIGKDD international conference on Knowledge discovery in data mining, 2005Online information services have grown too large for users to navigate without the help of automated tools such as collaborative filtering, which makes recommendations to users based on their collective past behavior. While many similarity measures have been proposed and individually evaluated, they have not been evaluated relative to each other in a ...
Ellen Spertus +2 more
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