Results 271 to 280 of about 9,169,557 (320)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Correlation Study of Co-opinion and Co-citation Similarity Measures

, 2019
Maryam Yaghtin, Hajar Sotudeh, Mehdi Mohammadi, Mahdieh Mirzabeigi, Seyed Mostafa Fakhrahmad   +4 more
openalex   +1 more source

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Constrained Pythagorean Fuzzy Sets and Its Similarity Measure

IEEE transactions on fuzzy systems, 2021
Pythagorean fuzzy set (PFS) is an extension of the intuitionistic fuzzy set. It has a wider space of membership degrees. Thus, it is more capable in expressing and handling the fuzzy information in engineering practice and scientific research.
Lipeng Pan, Xiaozhuan Gao, Yong Deng, K. Cheong   +3 more
semanticscholar   +1 more source

A new similarity measure for vector space models in text classification and information retrieval

Journal of information science, 2020
There are various models, methodologies and algorithms that can be used today for document classification, information retrieval and other text mining applications and systems.
Mete Eminağaoğlu
semanticscholar   +1 more source

Similarity Measure-Based Possibilistic FCM With Label Information for Brain MRI Segmentation

IEEE Transactions on Cybernetics, 2019
Magnetic resonance imaging (MRI) is extensively applied in clinical practice. Segmentation of the MRI brain image is significant to the detection of brain abnormalities. However, owing to the coexistence of intensity inhomogeneity and noise, dividing the
X. Bai, Yuxuan Zhang, Haonan Liu, Zhiguo Chen   +3 more
semanticscholar   +1 more source

Similarity measure for soft matrices and its applications

Journal of Intelligent & Fuzzy Systems, 2018
In this paper, the symmetric difference operation for each of the soft sets and the soft matrices is defined and then their related properties are derived. Also, the concept of similarity measure for the soft matrices is introduced.
Hüseyin Kamacı
semanticscholar   +1 more source