Results 91 to 100 of about 1,207,341 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Impact of trigonometric similarity measures for pythagorean fuzzy sets and their applications [PDF]

Yugoslav Journal of Operations Research
In fuzzy set theory, the similarity measure is a significant device that measures the degree of correlation between two objects. An extension to intuitionistic fuzzy sets (IFS), Pythagorean fuzzy sets (PFS) have been widely employed in numerous ...
Arora Hari Darshan, Kumar Vijay, Naithani Anjali   +2 more
doaj   +1 more source

Evaluating molecular similarity measures: Do similarity measures reflect electronic structure properties?

Journal of Chemical Information and Modeling
The rapid adoption of big data, machine learning (ML), and generative artificial intelligence (AI) in chemical discovery has heightened the importance of quantifying molecular similarity. Molecular similarity, commonly assessed as the distance between molecular fingerprints, is integral to applications such as database curation, diversity analysis, and
Rebekah Duke, Chih-Hsuan Yang, Baskar Ganapathysubramanian, Chad Risko   +3 more
openaire   +2 more sources

Measuring Global Similarity Between Texts [PDF]

, 2014
We propose a new similarity measure between texts which, contrary to the current state-of-the-art approaches, takes a global view of the texts to be compared. We have implemented a tool to compute our textual distance and conducted experiments on several corpuses of texts.
Fahrenberg, Uli, Biondi, Fabrizio, Corre, Kevin, Jegourel, Cyrille, Kongshøj, Simon, Legay, Axel   +5 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Additive similarity measures

Discrete Applied Mathematics, 2003
Following the approach of Tversky's contrast model, similarity measures are introduced as order-preserving maps from specific ordered sets into the non-negative reals. The analysis of this class of functions gives rise to the definition of additive similarity measures that induce a matroid on their domain. Here the author gives a representation of this
openaire   +1 more source

Efficient Nearest Neighbor Classification Using a Cascade of Approximate Similarity Measures [PDF]

, 2005
Nearest neighbor classification using shape context can yield highly accurate results in a number of recognition problems. Unfortunately, the approach can be too slow for practical applications, and thus approximation strategies are needed to make shape ...
Alon, Jonathan, Athitsos, Vassilis, Sclaroff, Stan   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Appropriate Similarity Measures for Author Cocitation Analysis [PDF]

We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory ...
Eck, N.J.P. van, Waltman, L.R.
core   +1 more source