Results 101 to 110 of about 1,243,483 (265)

Gaussian Kernel-Based LSH for High-Dimensional Similarity Search

IEEE Open Journal of the Computer Society
High-dimensional similarity search remains a critical challenge in machine learning, particularly when data lie on complex, non-linear manifolds that undermine the effectiveness of classical Locality-Sensitive Hashing (LSH). This work introduces Gaussian
Masrat Rasool, Khelil Kassoul, Samir Brahim Belhaouari   +2 more
doaj   +1 more source

Speed Up Similarity Search of Time Series Under Dynamic Time Warping

IEEE Access, 2019
Similarity search is a foundational task in time series data mining. Although there are many ways to measure the similarity of time series, a lot of evidence indicates that dynamic time warping (DTW) has the best robustness in many applications ...
Zhengxin Li, Jiansheng Guo, Hailin Li, Tao Wu, Sheng Mao, Feiping Nie   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search. [PDF]

Mol Imaging Biol, 2023
Janssen B, Tian G, Lengyel-Zhand Z, Hsieh CJ, Lougee MG, Riad A, Xu K, Hou C, Weng CC, Lopresti BJ, Kim HJ, Pagar VV, Ferrie JJ, Garcia BA, Mathis CA, Luk K, Petersson EJ, Mach RH.   +17 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

From Fact Drafts to Operational Systems: Semantic Search in Legal Decisions Using Fact Drafts

Big Data and Cognitive Computing
This research paper presents findings from an investigation in the semantic similarity search task within the legal domain, using a corpus of 1172 Hungarian court decisions.
Gergely Márk Csányi, Dorina Lakatos, István Üveges, Andrea Megyeri , János Pál Vadász, Dániel Nagy, Renátó Vági   +6 more
doaj   +1 more source

Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors. [PDF]

J Cheminform, 2023
Durai P, Lee SJ, Lee JW, Pan CH, Park K.
europepmc   +1 more source

Experiments in Diversifying Flickr Result Sets

, 2013
The 2013 MediaEval Retrieving Diverse Social Images Task looked to tackling the problem of search result diversification of Flickr results sets formed from queries about geographic places and landmarks.
Davies, Jamie, Dupplaw, David, Hare, Jonathon, Jain, Neha, Lewis, Paul H., Preston, John, Samangooei, Sina   +6 more
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