Results 111 to 120 of about 5,030,093 (326)
Citation: 'similarity searching' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11512 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Spatial selection of sparse pivots for similarity search in metric spaces
Journal of Computer Science and Technology, 2007 Similarity search is a fundamental operation for applications that deal with unstructured data sources. In this paper we propose a new pivot-based method for similarity search, called Sparse Spatial Selection (SSS). The main characteristic of this method
Nieves Rodríguez Brisaboa +3 more
doaj
Associative Memories to Accelerate Approximate Nearest Neighbor Search
Applied Sciences, 2018 Nearest neighbor search is a very active field in machine learning. It appears in many application cases, including classification and object retrieval.
Vincent Gripon +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Speed Up Similarity Search of Time Series Under Dynamic Time Warping
IEEE Access, 2019 Similarity search is a foundational task in time series data mining. Although there are many ways to measure the similarity of time series, a lot of evidence indicates that dynamic time warping (DTW) has the best robustness in many applications ...
Zhengxin Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
From Fact Drafts to Operational Systems: Semantic Search in Legal Decisions Using Fact Drafts
Big Data and Cognitive ComputingThis research paper presents findings from an investigation in the semantic similarity search task within the legal domain, using a corpus of 1172 Hungarian court decisions.
Gergely Márk Csányi +6 more
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