Results 121 to 130 of about 5,030,093 (326)

Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search. [PDF]

Mol Imaging Biol, 2023
Janssen B, Tian G, Lengyel-Zhand Z, Hsieh CJ, Lougee MG, Riad A, Xu K, Hou C, Weng CC, Lopresti BJ, Kim HJ, Pagar VV, Ferrie JJ, Garcia BA, Mathis CA, Luk K, Petersson EJ, Mach RH.   +17 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Experiments in Diversifying Flickr Result Sets

, 2013
The 2013 MediaEval Retrieving Diverse Social Images Task looked to tackling the problem of search result diversification of Flickr results sets formed from queries about geographic places and landmarks.
Davies, Jamie, Dupplaw, David, Hare, Jonathon, Jain, Neha, Lewis, Paul H., Preston, John, Samangooei, Sina   +6 more
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Billion-Scale Similarity Search Using a Hybrid Indexing Approach with Advanced Filtering

Cybernetics and Information Technologies
This paper presents a novel approach for similarity search with complex filtering capabilities on billion-scale datasets, optimized for CPU inference. Our method extends the classical IVF-Flat index structure to integrate multi-dimensional filters.
Emanuilov Simeon, Dimov Aleksandar
doaj   +1 more source

COMPUTATION OF IMAGE SIMILARITY WITH TIME SERIES [PDF]

ICTACT Journal on Image and Video Processing, 2011
Searching for similar sequence in large database is an important task in temporal data mining. Similarity search is concerned with efficiently locating subsequences or whole sequences in large archives of sequences.
V. Balamurugan, K. Senthamarai Kannan, S. Selvakumar   +2 more
doaj  

Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors. [PDF]

J Cheminform, 2023
Durai P, Lee SJ, Lee JW, Pan CH, Park K.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

SIMBSIG: similarity search and clustering for biobank-scale data. [PDF]

Bioinformatics, 2023
Adamer MF, Roellin E, Bourguignon L, Borgwardt K.   +3 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source