Results 141 to 150 of about 1,243,483 (265)
, 2000 Similarity searching is fundamental in various application areas. Recently it has attracted much attention in the database community because of the growing need to deal with large volume of data. Consequently, efficiency has become a matter of concern in design.
openaire +2 more sources
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Improving Performance of Local Chatbot with Caching [PDF]
Journal of Systemics, Cybernetics and InformaticsChatbots and the technology behind them are widely used in many places and in various ways. Retrieval Augmented Generation AI framework has gained its popularity by its linking of large language model with private dataset.
John Jenq
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FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
PZLAST: an ultra-fast amino acid sequence similarity search server against public metagenomes. [PDF]
Bioinformatics, 2021 Mori H +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
SMILES-based 2D-QSAR and similarity search for identification of potential new scaffolds for development of SARS-CoV-2 MPRO inhibitors. [PDF]
Struct Chem, 2022 Costa AS, Martins JPA, de Melo EB.
europepmc +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Optimizing the spatial approximation tree from the root
Journal of Computer Science and Technology, 2008 Many computational applications need to look for information in a database. Nowadays, the predominance of nonconventional databases makes the similarity search (i.e., searching elements of the database that are "similar" to a given query) becomes a ...
Alejandro J. Gómez +2 more
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