Results 41 to 50 of about 325,256 (164)

Optimal neighborhood indexing for protein similarity search

open access: yesBMC Bioinformatics, 2008
Background Similarity inference, one of the main bioinformatics tasks, has to face an exponential growth of the biological data. A classical approach used to cope with this data flow involves heuristics with large seed indexes.
Nguyen Van   +5 more
doaj   +1 more source

In silico target identification and pharmacokinetic profiling of 2-aryl-quinoline-4-carboxylic acid derivatives as potential antileishmanial agents

open access: yesFrontiers in Pharmacology
IntroductionLeishmaniasis remains a major neglected tropical disease, and new therapeutic strategies are urgently needed. This study aimed to identify the molecular target of 2-aryl-quinoline-4-carboxylic acid derivatives and assess their pharmacokinetic
Marília Cecília da Silva   +8 more
doaj   +1 more source

Hard problems in similarity searching

open access: yesDiscrete Applied Mathematics, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Moan, Christophe, Rusu, Irena
openaire   +4 more sources

Hashing for Similarity Search: A Survey

open access: yesCoRR, 2014
Similarity search (nearest neighbor search) is a problem of pursuing the data items whose distances to a query item are the smallest from a large database. Various methods have been developed to address this problem, and recently a lot of efforts have been devoted to approximate search.
Jingdong Wang 0001   +3 more
openaire   +2 more sources

A Network View on the Big Exchange Project: Integrating and Analysing Heterogeneous Datasets

open access: yesJournal of Computer Applications in Archaeology
This study presents a proof-of-concept for integrating 14 datasets on 11 archaeologically relevant raw materials from the Big Exchange project into a heterogeneous information network (HIN), an informational structure explicitly modelling multiple object
Mattis thor Straten   +5 more
doaj   +1 more source

Spreading vectors for similarity search

open access: yes, 2018
Discretizing multi-dimensional data distributions is a fundamental step of modern indexing methods. State-of-the-art techniques learn parameters of quantizers on training data for optimal performance, thus adapting quantizers to the data. In this work, we propose to reverse this paradigm and adapt the data to the quantizer: we train a neural net which ...
Sablayrolles, Alexandre   +3 more
openaire   +4 more sources

Center selection techniques for metric indexes

open access: yesJournal of Computer Science and Technology, 2007
The metric spaces model formalizes the similarity search concept in nontraditional databases. The goal is to build an index designed to save distance computations when answering similarity queries later. A large class of algorithms to build the index are
Cristian Mendoza Alric   +1 more
doaj  

Discovery of Novel Small-Molecule Compounds with Selective Cytotoxicity for Burkitt’s Lymphoma Cells Using 3D Ligand-Based Virtual Screening

open access: yesMolecules, 2014
We describe a ligand-based approach towards compounds with more specific targeting for Burkitt’s lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are ...
Martina Gobec   +5 more
doaj   +1 more source

Combinatorial Framework for Similarity Search [PDF]

open access: yes2009 Second International Workshop on Similarity Search and Applications, 2009
We present an overview of combinatorial framework for similarity search. An algorithm is combinatorial if only direct comparisons between two pairwise similarity values are allowed. Namely, the input dataset is represented by a comparison oracle that given any three points X,Y,Z answers whether Y or Z is closer to X. We assume that the similarity order
openaire   +1 more source

Spatial selection of sparse pivots for similarity search in metric spaces

open access: yesJournal of Computer Science and Technology, 2007
Similarity search is a fundamental operation for applications that deal with unstructured data sources. In this paper we propose a new pivot-based method for similarity search, called Sparse Spatial Selection (SSS). The main characteristic of this method
Nieves Rodríguez Brisaboa   +3 more
doaj  

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