Results 201 to 210 of about 453,861 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

16S rRNA-based genetic diversity and symbiotic efficiency of indigenous cowpea-nodulating rhizobia from semiarid Eastern Kenya. [PDF]

Front Microbiol
Khater AK, Kirui CK, Njeru EM, Githiri SM.   +3 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Chemical Pattern Recognition and Color-Chromaticity Correlation Analysis for Quality Control of Stir-Fried Perillae Fructus. [PDF]

Molecules
Li L, Deng X, Wang P, Zeng N, Hu J.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Revisiting motif finding: do bi-objective metaheuristics surpass single-objective metaheuristics? [PDF]

BMC Bioinformatics
Nayeem MA, Ahmed SS, Aladhadh S, Rahman MS.   +3 more
europepmc   +1 more source

Tracking the dynamic evolution of lithium-ion battery recycling technology using natural language processing. [PDF]

Sci Rep
Yan J, Zhang Z.
europepmc   +1 more source

Identifying the necessary conditions for large populations to enhance cumulative culture. [PDF]

Sci Rep
Walker B, Fay N.
europepmc   +1 more source

Neuroimaging-Based Subgroups in Schizophrenia: A Critical Appraisal of Clustering Studies. [PDF]

Biol Psychiatry Glob Open Sci
Yu Y, Ge R, Frangou S.
europepmc   +1 more source

Reading the climate room through unsupervised analysis of unfiltered climate perspectives. [PDF]

Sci Rep
Sweeney L, Mehrotra R, Saintraint F, Brennan RA, Suiter J.   +4 more
europepmc   +1 more source