Results 171 to 180 of about 198,995 (264)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Kaminari: a frugal colored index for approximate <i>k</i>-mer queries. [PDF]

Bioinform Adv
Levallois V, Shibuya Y, Le Gal B, Dufresne Y, Patro R, Peterlongo P, Pibiri GE.   +6 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Semantic knowledge guides innovation and drives cultural evolution. [PDF]

Proc Natl Acad Sci U S A
Yaman A, Tian S, Lindström B.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A User-Centered Interface Design Framework for the DELONELINESS System in Older Adults: Design Indicator Development and Prioritization. [PDF]

JMIR Hum Factors
Zhou Y, Rees J, Matcham F, Antonelli M, Ourselin S, Liu W.   +5 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Comparative analysis of artificial intelligence-based contouring of cardiac substructures on computed tomography scans for radiation therapy. [PDF]

Phys Imaging Radiat Oncol
Moignier A, Perennec T, Prangères E, Bernard B, Botticella A, Chen X, Finnegan R, Huger S, Karlhede A, Lacornerie T, Löfman F, Palisson J, Robert C, Sambourg K, Söderberg J, Stoica R, Delpon G, Martin-Mervoyer E, Thillays F, Vaugier L.   +19 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Equivariant diffusion solution for inorganic crystal structure determination from powder X-ray diffraction data. [PDF]

Nat Commun
Yu D, Zhu Z, Leng F, Zhu Y.
europepmc   +1 more source