Results 171 to 180 of about 6,208,817 (342)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Harmonizing results of ataxia rating scales: mFARS, SARA, and ICARS

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2041-2046, December 2022., 2022
Abstract The ever‐increasing body of ataxia research provides opportunities for large‐scale meta‐analyses, systematic reviews, and data aggregation. Because multiple standardized scales are used to quantify ataxia severity, harmonization of these measures is necessary for quantitative data pooling. We applied the modified Friedreich Ataxia Rating Scale
Christian Rummey   +5 more
wiley   +1 more source

Triangle groups and finite simple groups

open access: yes, 2009
This thesis contains a study of the spaces of homomorphisms from hyperbolic triangle groups to finite groups of Lie type which leads to a number of deterministic, asymptotic, and probabilistic results on the (p1, p2, p3)-generation problem for finite groups of Lie type.
Marion, Claude Miguel Emmanuel   +1 more
openaire   +4 more sources

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

open access: yesFEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo   +2 more
wiley   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

A counterexample for the conjecture of finite simple groups [PDF]

open access: yesarXiv, 2018
In this note we provide some counterexamples for the conjectures of finite simple groups, one of the conjectures said "all finite simple groups $G$ can be determined using their orders $|G|$ and the number of elements of order $p$, where $p$ the largest prime divisor of $|G|$".
arxiv  

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

open access: yesFEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma   +3 more
wiley   +1 more source

ON A GROUP EXTENSION INVOLVING THE SPORADIC JANKO GROUP \(J_{2}\)

open access: yesUral Mathematical Journal
Using the electronic Atlas of Wilson [21], the group J_2 has an absolutely irreducible module of dimension 6 over F_4. Therefor a split extension group of the form 4^6:J_2:= \bar{G} exists.
Ayoub B. M. Basheer
doaj   +1 more source

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